• Determination of Frequency of Human Papillomavirus Infection and it's genotypes among Patients with Prostate Cancer in Bushehr Province, 2010-2018
  • Fatemeh Farshadpour,1 Reza Taherkhani,2,*
    1. Department of Virology, School of Medicine, Bushehr University of Medical Sciences
    2. Department of Virology, School of Medicine, Bushehr University of Medical Sciences


  • Introduction: Background and aims: Prostate cancer is one of the most important malignant tumors in men and is the second common cancer among men throughout the world. The role of infectious agents and oncoviruses such as human papillomaviruses in contaminating prostate regions, which can occur as a result of dissemination from contaminated anogenital areas or through blood or lymph, is mentioned as a potential risk factor for prostate cancer. This study was conducted to determine the prevalence and genotype distribution of human papillomavirus in paraffin-embedded tissue specimens from patients with prostate cancer in an 8-year period in Bushehr province using nested-PCR technique.
  • Methods: Materials and Methods: This study is a descriptive cross-sectional study. The study population includes paraffin-embedded prostate specimens of patients with prostate cancer referred to the Shohadaie Khalij-Fars Hospital in Bushehr during 2010 to 2018. Cancerous paraffin-embedded tissue specimens from 49 patients and 170 non-cancerous paraffin-embedded tissue samples (Hyperplasia with and without inflammatory tissue specimens) as control group were investigated for nested PCR method. Data were analyzed using SPSS software, Chi-square and Fisher's statistical tests.
  • Results: Results: The mean age of 49 patients with prostate cancer, who were investigated in molecular analysis, was 73.2 ± 8.2 years (with age range from 50 to 85 years). Most of the patients were between the ages of 70-79 years and then over 80 years. Most cases of prostate cancer were from 2013. In terms of Gleason score, the highest prevalence of prostate carcinoma was with a Gleason score equal to and greater than 8, followed by Gleason score equal to and lower than 6. The overall prevalence of HPV infection in 49 malignant prostate cancer cases was 4.1% (2 cases). Out of 170 non-cancerous prostate tissue samples (control group), HPV infection was observed in two cases, and the overall prevalence of HPV in the control group was 1.2%.
  • Conclusion: Conclusion: The overall prevalence of HPV infection in adenocarcinoma prostate samples and in the control group was very low. In addition, there was no significant statistically relationship between age, city, year and types of malignant and benign prostate lesions with the prevalence of HPV infection (p value> 0.05). Therefore, the role of other risk factors for prostate cancer such as age, diet, genetic factors and environmental factors may be more important than the role of human papillomavirus in the development of prostate cancer.
  • Keywords: Human Papillomavirus, Prostate Cancer, Bushehr province, nested-PCR technique