Mesenchymal Stem Cells-Conditioned Medium; An Effective Cell-Free Therapeutic Option for in Vitro Maturation of Oocytes
Mesenchymal Stem Cells-Conditioned Medium; An Effective Cell-Free Therapeutic Option for in Vitro Maturation of Oocytes
Maryam Farzaneh,1,*
1. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Introduction: Infertility is a major reproductive health issue, worldwide. One of the main problems in infertile women is the failure to generate or release a mature egg. Therefore, the development of new technologies for in vitro generation or induction of mature oocytes can improve various ART procedures. Recently, stem cell-based therapy has opened a new window for several pathological complications. Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity to self-renew and differentiate into the mesodermal lineage. MSCs contains various bioactive molecules, which are involved in the regulation of key biological processes. They can secret multiple growth factors and cytokines to stimulate egg maturation. Although MSCs represent a promising source for cell therapy, the potential risk of tumor development reduced their clinical applications.
Methods: Recent studies have suggested that the supernatant or conditioned medium of MSCs also contains similar components and regulates the oocyte behavior. MSC-conditioned medium can eliminate the safety concerns associated with MSC transplantation and avoid rejection problems.
Results: MSCs have been shown to improve oocyte quality, ovarian function, and fertility.
Conclusion: Hereby, we summarized recent research findings of MSCs-derived conditioned medium in in vitro development of immature oocytes.