Photodynamic effects of Rose bengal on cancer cells lines
Photodynamic effects of Rose bengal on cancer cells lines
Parnia Hemmati,1,*Seyed Mehdi Tabaie,2Mina Sadat Naderi,3
1. Department of Cell and Molecular Biology, Faculty of Biological Sciences, Islamic Azad University, Tehran North Branch, Tehran, IRAN 2. Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, IRAN 3. Department of Biophysics, Faculty of Biological Sciences, Islamic Azad University, Tehran North Branch, Tehran, IRAN
Introduction: Introduction:
Cancer is one of the leading causes of death worldwide. Cancer causes uncontrolled cell division, which can lead to tumors, damage to the immune system, and other fatal disorders.
Cancer is recognized as a major cause of death and an important barrier to increasing life expectancy in every country in the world.
There are several treatments for cancer. One of these methods is photodynamic therapy (PDT). Photodynamic therapy (PDT) is a promising minimally invasive treatment for cancer that uses non-ionizing radiation (in most cases) and its cytotoxic mechanisms cause limited damage to DNA and connective tissue structures and collagen. This treatment can be used as many times as needed by doctors, something that is not possible with current treatments (surgery, chemotherapy and radiotherapy). PDT does not have a "memory effect" as radiation therapy.This treatment involves the administration of a light-sensitizing agent (PS) and the subsequent stimulation of the PS with laser light at a specific wavelength. The evoked PS then reacts with cellular oxygen and produces reactive oxygen species (ROS)which kill tumor cells by direct and indirect cell death mechanisms.
Ps sensitizers are used in various photodynamic therapies. One of these sensitizers is Rose bengal. Bengal rose (4,5,6,7-tetrachloro-2%, 4%, 5%, 7% -tetraiodo-fluorescein disodium or RB) is a known type II light sensitizing agent and thanks to the presence of several chlorine and Iodine on xanthine rings shows easy photocatalytic conversion of triple oxygen. Bengal rose has also been used as a treatment for some cancers and skin diseases. Rose Bengal has also been used as a light sensor in the photodynamic therapy of breast cancer. In this method, laser green light has been used.
According to the articles, Rose bengal has also been used as a sensitizer in the treatment of A375 cell line (human melanoma cell line) and direct sunlight has been used instead of laser light. Larynx cancer also uses the Rose bengal sensitizer and green light laser, and the number of cancer cells to the extent
Decreased upper.
Methods: Methodology: This literature review was a cross-sectional study by popular search engines in medical sciences include PubMed, Science Direct, Google Scholar, Elsevier, and Scopus over the past 5 years .
Results: Result: Rose bengal medicine can be used to treat some cancers such as skin, breast, larynx as well as skin diseases.
Conclusion: Discussion: According to review studies, it can be concluded that some drugs such as Rose Bengal due to their structural and chemical properties can play a role as a light sensitizer in the treatment of many cancers by photodynamic methods. And this study can be useful in improving treatment methods.