Introduction: Cancer cells are different from normal cells in various ways. An unusual change in the division cycle of cancer cells has caused a change in the life process of the organism. Sometimes, cancer cells may be so-called benign and will not have many abnormal effects on the body's metabolism. In some cases, cancer cells are malignant and they act as invaders, which will endanger the metabolism of other cells.
In recent years, extensive studies have been conducted on cancer. One of the most important unique behavior of cells is when cancer occurs. Cell suicide is one of the most important of these methods. In this mechanism, cells commit cell suicide through molecular pathways
Methods: Library Studies
Reading various articles from reliable databases such as SID, Scopus,...
Results: Results obtained from human cancer cells show that inhibition of ERK5 activates "cytotoxic autophagy". Cytotoxic autophagy is a process that initiates the destruction of cancer cells without affecting healthy cells. Combination of ERK5 inhibitors and chemotherapy can improve cancer treatment.
Conclusion: Inhibiting the progression of cancer and helping to cure the disease