• Investigating the effect of amiodarone drug on IRBIT protein by molecular docking method
  • Golnaz harati,1,*
    1. Golnaz harati Cellular and molecular biology faculty of biological Sciences, Parand Islamic Azad University. Golnazharati6@gmail.com


  • Introduction: Introduction: Amiodarone, a potent antiarrhythmic drug useful for both atrial and ventricular arrhythmias, has a combination of β-blocking, calcium channel blocking, and class III antiarrhythmic effects. In patients with acute onset of AF and also with left ventricular dysfunction, amiodarone or digoxin is recommended due to minimal negative inotropic effect. Amiodarone has serious systemic side effects. In addition, amiodarone is associated with a high mortality rate in patients with acute or chronic heart failure.(1) IRBIT (Inositol 1,4,5-trisphosphate-released IP3R binding protein) was identified as a molecule that regulates Ca2+ concentration by competing with IP3 for the IP3 1,2 receptor. Given that the activities of various ion transporters are regulated by IRBIT in a phosphorylation-dependent manner, IRBIT can act as both a sensor and an integrative modulator of the intracellular ionic environment.(2) The purpose of this study is to investigate the bioinformatics effect of amiodarone on IRBIT protein. Material and method: This research was carried out using a descriptive analytical method. In this study , To check the chemical structure of the protein, visit www. uniprot. org we use. And to check the structure of amiodarone from pubchem. ncbi. nlm. nih. gov we used. Also from the software chimera1.10 and PyRx were also used.
  • Methods: Material and method: This research was carried out using a descriptive analytical method. In this study , To check the chemical structure of the protein, visit www. uniprot. org we use. And to check the structure of amiodarone from pubchem. ncbi. nlm. nih. gov we used. Also from the software chimera1.10 and PyRx were also used.
  • Results: Result:In this study, In this study, we come to the conclusione that because amiodarone binding energy level is -6.0 . AND ALSO had 9 results and RMSD was zero ,which shows that drug amiodarone has a btter effect on the IRBIT protein
  • Conclusion: conclusion: In this study, we came to the conclusion that amiodarone drug has the best effect on IRBIT protein
  • Keywords: DOcking , Amiodarone , IRBIT Protein, Bioanformatics,