مقالات پذیرفته شده در ششمین کنگره بین المللی زیست پزشکی
Bacteria and Cancer
Bacteria and Cancer
Farzaneh Dianatdar,1,*Mohammad Rabbani,2
1. Ph.D. Student of Microbiology, Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan. 2. Associate Professor, Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan.
Introduction: Genetic, environmental and dietary factors have often been studied to induce cancer, and the effect of bacteria on cancer has been less studied. In the past, bacteria were not thought to cause cancer. William Russell first reported the effect of bacterial infection on carcinogenesis in 1890. In 1926, Thomas Glover was able to isolate bacteria from pleomorphic organism and help treat cancer patients with antibacterial serum. Other scientists, such as William Coley, Gunther Enderlein, Josef Issels, Royal Rife, Florence and Seibert continued their research. Bacteria cause cancer by two mechanisms, including chronic inflammation and the production of carcinogenic bacterial metabolites. Helicobacter pylori causes gastrointestinal cancer by causing chronic inflammation in the stomach. Inflammation caused by H. pylori induces cell proliferation and also produces mutant free radicals that cause cancer. H. pylori has been identified as the first cancer bacteria by the International Agency for Research on Cancer. H. pylori, Salmonella typhi, Streptococcus bovis and Chlamydia pneumoniae cause gastric, gallbladder, colorectal and lung cancers by different mechanisms. Salmonella typhi causes gallbladder cancer by producing typhoid toxin and damage to DNA and changes in the cell cycle. Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola and Streptococcus anginosus cause oral cancer by causing chronic inflammation, increased cell proliferation, suppression of the immune system and production of carcinogens. Bacteria can also be used to treat cancer. Live, attenuated or genetically modified bacteria or anaerobic bacteria such as Clostridium and Bifidobacterium can be selectively colonized in tumors and fight cancer cells.
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Results: Pathogens cause cancer by producing carcinogens and inducing the immune system. Bacteria such as Fusobacterium spp, Borrelia burgdorferi, Escherichia coli, Mycoplasma spp, and Salmonella enterica can cause cancer. Bioengineering bacteria can also fight cancer by targeting cancer cells.
Conclusion: The hypothesis that the bacterial genome enters the human genome and causes cancer has not yet been confirmed and further studies are needed. Treatment of cancer with bacteria has disadvantages such as pathogenicity, negative interaction with chemical drugs and genetic changes of microbes.