• Long Term Resistance Training has positive effects on Cardiac, Forceps Striated Muscles, microscopic changes in the liver and Kidney of male rats
  • Saber Ghaderpour,1 Rafighe Ghiasi,2,*
    1. Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
    2. Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran


  • Introduction: Background and Aims: Resistance exercise, known as stretching and weight training, is a special method designed to increase traction and muscle endurance. In response to this type of exercise, skeletal and cardiac muscles adapt and beneficial physiological changes occur in other tissues. This study was conducted to evaluate the effects of Long Term Resistance Training on Pathological and Ultrastructural changes of Cardiac, Forceps Striated Muscles, Microscopic Changes of Liver and Kidney.
  • Methods: Twenty adult male Wistar rats were randomly divided into control and exercise groups. The exercise group performed Long Term Resistance Training for 4 months. At the end of the course, the animals were first anesthetized and then autopsied and isolated tissues such as heart muscle, Forceps muscle of the right leg, liver, and kidney are performed and the isolated tissues are stabilized in 10% neutral buffer in formalin solution. After tissue preparation and preparation of paraffin blocks, sections with a thickness of 5 microns are prepared and transferred to the slide and after staining by the hematoxylin-eosin (H&E) method are studied by light microscopy.
  • Results: Histopathological changes in liver tissue in the control group included mild hyperemia. The liver also showed mild degrees of reactivity, with an increase in the size and number of kupffer cells. The infiltration and settlement of neutrophils were visible in the disse space. The liver tissue in the exercise group showed mild hyperemia, the severity of hyperemia was slightly higher than the control group. In exercise group, the liver also showed mild degrees of reactivity, with an increase in the size and number of Kupffer cells. Also, the infiltration and settlement of neutrophils in the disse space was visible. Sinusoid dilation and mild fat change were also observed. In the control group, no complications were seen in cardiac tissue except hyperemia. In the cardiac tissue of the exercise group, mild hyperemia, mild degeneration of the cardiac muscle cells, mild lesions with a transverse cross-section of the muscle cells, and greater staining and hyaline of these cells were seen. Compared with the control group, muscle cell hypertrophy was observed in this group. The Forceps muscle tissue in the control group showed hyperemia. The Forceps muscle tissue of the exercise group showed mild hyperemia, mild damage lesions with loss of transverse muscle cell translocation, and greater staining and hyaline depletion of these cells. Compared with the control group, muscle cell hypertrophy was highly observed in this group. In the renal tissue of the control group, no complication was observed except mild hyperemia. Also, In the histopathological study of kidney tissue, mild hyperemia was seen in the exercise group. No increase in renal glomerular diameter (renal body) was observed in the four-month group.
  • Conclusion: In general, long-term exercise in male rats had positive effects on body tissues.
  • Keywords: Long-term exercise, Cardiac tissue, liver tissue, Forceps Striated Muscle, kidney tissue.