• Diagnosis and treatment of cancer using microorganisms
  • Meshkat Torkashvand,1,*
    1. Islamic Azad University, Shahr Quds Branch, Tehran


  • Introduction: cancer is a group of diseases that arise as a result of uncontrolled proliferation of transformed cells and is one of the most common causes of death, and it shows that we should look for a new way to treat it, which we are investigating bacterial therapy. . This method is non-invasive and it is possible to work on changing their ability in genetic engineering. Example: release of specific compounds and changes in metabolite pathways. Secretion of toxins and enzymes, including lipase and protease, and its effect on the hypoxic area of the tumor. A combination of bacteriotherapy and radiotherapy or immunotherapy can also be an effective method.
  • Methods: This is a research and review with PubMed and Google, the focus of which is the diagnosis and treatment of cancer using microorganisms.
  • Results: Probiotics are the most well-known microorganisms in the treatment of cancer and by, changing the intestinal flora, they reduce the absorption of carcinogenic and mutagenic substances, and Salmonella typhimurium has an anti-mutagenic effect, and in relation to the coagulation bacillus, with or without the presence of S9, between -40 50% and in relation to Lactobacillus acidophilus between 50-55% anticancer effect. Salmonella and Clostridium are effective in controlling tumor growth and increasing survival in animal models.
  • Conclusion: Bacteriotherapy method: A:Proliferation of tumor-specific bacteria which has the least negative effect on healthy cells B:Plasmid DNA transfer to mammalian cells by bacteria C:Use of tetanus, botulonium and diphtheria bacterial toxins in two bacterial methods and bacterial toxins that bind to tumor surface antigen The location of bacterial colony formation allows the detection of metastatic tumors by 4methods: bioluminescence, fluorescence, magnetic resonance and positron radiation. Transferring plant cytochrome P450 to E.coli bacteria can also turn it into an anti-cancer drug factory.
  • Keywords: cancer, Probiotics , Bacteriotherapy ,microorganisms