• Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma
  • Sepideh Asadi,1 Sana Falahi,2 Seyede mahsa chavoshi,3 Mohaddese Gafourifard,4 Elaheh Oliyaei,5 HadisTolomehr,6,*
    1. BSc student of Laboratory Sciences, Student Research Committee, Sarab Faculty of Medical Sciences, Sarab, Iran
    2. BSc student of Laboratory Sciences, Sarab Faculty of Medical Sciences, Sarab, Iran
    3. BSc student of Laboratory Sciences, Qazvin University of medical sciences, Qazvin, Iran
    4. BSc student of Laboratory Sciences, Sarab Faculty of Medical Sciences, Sarab, Iran
    5. Faculty of Paramedicine, Department of medicine, Bushehr University of Medical Science, Bushehr, Iran
    6. BSc student of Laboratory Sciences, Mazandaran University of Medical sciences, Sari, Iran


  • Introduction: Neuroblastomas (NB) is the most now no longer unusual place area of pediatric malignancy identified earlier than the number one birthday, which represents approximately 6% of all cancers in children, is more now no longer unusual place area in boys than in girls. This most now commonplace area, greater cranial teens robust tumor, has a presumable molecular starting area with withinside the sympathoadrenal lineage of the neural crest subsequently of development. Cells and tissues are continuously monitored through a manner of way of an ever-alert immune device. In the tool of maximum cancers' progression, however, robust tumors have tailor-made to the selection strain exerted through manner of way of the immune device and characteristic superior the potential to avoid it. Glycosylation is the enzymatic tool responsible for the attachment of glycan to proteins, lipids, or exquisite saccharides. Glycan and glycoproteins have been significantly used withinside the hospital as each stratification and evaluation of maximum cancers biomarkers. Given the essential characteristic of glycan in tumor biology, together with its microenvironment and the immune response regulation, it has emerged as apparent that glycosylation modifications taking area in maximum cancers want to have a high-quality impact on maximum cancers' treatment.
  • Methods: In the forthcoming systematic study, the required data were collected using keywords and citing valid databases such as: Scopus PubMed, Google Scholar and ProQuest. The statistical population of the study includes all studies conducted up to 2022 in the field of Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma. After reviewing the relevant findings and evaluating the data quality, a total of 17 articles were analyzed.
  • Results: Changes in glycosylation on proteins or lipids are one of the hallmarks of tumorigenesis which can also furthermore need to modulate inflammatory responses, permit viral immune escape, promote maximum cancer's mobileular metastasis or alter apoptosis. Functionally, glycans control or have an impact on several factors of maximum cancer's mobileular biology, starting from mobileular adhesion, extracellular matrix interactions, mobileular signaling and proliferation, and proximal and distal communication. These natural techniques underlie essential maximum cancers hallmarks which incorporates invasion, angiogenesis, and metastasis formation, along the development of allowing maximum cancer's abilities together with the modulation of the immune response. Identification of glycan structures at unique sites, and its abundance in a protein. Apart from these, the development of effective synthetic machine for analyzing the effect of glycosylation on shape and abilities of biomolecules is as an opportunity tough due to the fact multiple isoforms of glycosyltransferases can encode an unmarried glycan epitope.
  • Conclusion: Maximum cancers-associated glycoforms and glycotransferases associated with the synthesis of such glycans have capability use for drug discovery glycosylation research come upon several challenges, which incorporates identifying unique natural results of expression patterns and levels of glycosyltransferases/glycosidases; While research on this area stays in its early levels, many studies have illustrated that Protein glycosylation has emerged as a promising cause for max cancers treatment and each in treatment and withinside the biomarker area unfold out a cutting-edge manner of thinking for treatment of the 1/3 most not unusual place area teens maximum cancers. Further investigations of most cancer's unique glycans are hoped to boom more beneficial prognostic, diagnostic, and recovery goals withinside the fight withinside the path of maximum cancers.
  • Keywords: Protein glycosylation, cancer, neuroblastoma, treatment, Protein Disulfide-Isomerases