Epigenetics advancing personalized nanomedicine in cancer therapy

Epigenetics advancing personalized nanomedicine in cancer therapy
Mohamadreza Shabani,^1,* Arash Azizinezhad,² Farid Jahanshahlou,³ Elaheh Oliyaei,⁴ Farzane Abdollahi,⁵
1. Shahid sadooghi university of medical science
2. Universal scientific education and research network (USERN)
3. Student Research Committee
4. Faculty of Paramedicine, Department of medicine, Bushehr University of Medical Science, Bushehr, Iran
5. Shahid Beheshti University of Medical Sciences, Tehran, Iran
Introduction: Epigenetic changes are introduced as a shape of genetic extrude in chromatin and therefore genes, if it does now not have an effect on the totality of the gene, but impacts the way the gene is expressed. In the studies completed on a fertilized egg, they were able to use genetic and epigenetic codes, turn the egg into natural components, which incorporates tissues, organs with specific structures and functions. Since first-class 0. 1% of the human genome is specific, if it changes, we see plenty of range with interior the human population. According to WHO, maximum cancers is taken into consideration as a severe hazard to human fitness with inside the international and is known as the second one purpose of death. The prevalence of numerous life-threatening cancers is increasing, genuinely so with inside the USA in 2018, we placed 17 million human beings laid low with maximum cancers. Among maximum cancers treatments, that could purpose epigenetic changes in an individual. The survival price of maximum cancers patients has superior little with inside the past, and we need new thoughts and strategies for maximum cancers' treatment. One of the treatments for maximum cancers and special illnesses is the treatment based totally absolutely, absolutely on epigenetic changes the use of custom designed remedy and little studies It has been completed due to its importance. The essential emphasis of this article is to create a connection among custom designed and with medication with regard to epigenetic changes in maximum cancers' management.
Methods: In the forthcoming systematic study, the required data were collected using keywords and citing valid databases such as: Scopus PubMed, Google Scholar and ProQuest. The statistical population of the study includes all studies conducted up to 2022 in the field of Epigenetics advancing personalized Nano medicine in cancer therapy. After reviewing the relevant findings and evaluating the data quality, a total of 22 articles were analyzed.
Results: Cancer manifests itself with inside the shape of hypo methylation in DNA and CPG and histone changes. Chemotherapy and radiotherapy are a few of the strategies to cope with maximum cancers, which due to the effect on epigenetics, purpose changes in gene expression, genetic mutations and instability in chromosomes. Today, new fields for maximum cancers' treatment are being created, which want It has superior the lives of patients and is used no longer first-class for the treatment of cancers but moreover for the treatment of illnesses together with kind 2 diabetes. The answer is treatment in specific human beings and predicting difficulty effects of drugs through scientific trials and discovery of latest drugs.
Conclusion: The essential emphasis of this article is to create a connection Today, NATO medication and epigenetic-based totally absolutely genuinely treatments are particularly have become used that first-rate changes were made in maximum cancers patients, but the survival of maximum cancers patients has now not changed with the ones treatments, and consistent with this difficulty, specific treatments based totally mostly on the aggregate of custom designed treatment in NATO medication and epigenetics. Consistent with the evidence, shows successful customized remedy because it specializes with inside the specific dispositions of absolutely everyone and their genetics. The truth that a large thing of the scientific and natural dispositions associated with the affected individual is even though unknown can motive the perception that focused treatments have failed. Customized NATO medication based totally mostly on Epigenetics is a suitable opportunity for scientific programs on patients with numerous illnesses. We want to supply effective treatments to patients with the improvement of knowledge related to genetic changes and the development of custom designed NATO medication.
Keywords: biomimetic nanoparticles, personalized nanomedicine, Epigenetics, nanomedicine, cancer therapy