Introduction: Arsenic is one of the most dangerous elements in the world and it is combined in nature and we can find it in the earth's crust, especially in groundwater and soil.
Arsenic is also released when coal is burned, but today more arsenic reaches our bodies because the rice we eat now contains arsenic.
But what is important is that arsenic is a carcinogenic substance that directly affects DNA and causes skin, bladder, and bladder cancer by induction. Also, arsenic compounds cause dysfunction in some body organs such as the liver, digestive tract, kidneys, and bladder. And the respiratory system and its effect on the pancreas to produce insulin can be mentioned that eventually the person will get type 2 diabetes.
Methods: The effect of arsenic on cancer: Arsenic is involved in the beginning of cancer through the induction of oxidative stress and the production of ROS
Methylation of arsenic by adenosylmethionine and glutathione produces highly toxic methylated species, arsenic with strong cytotoxic activity and enzyme inhibitory effect causes epigenetic effects such as histone changes and DNA methylation. Arsenic is able to bind to sulfhydrylcysteine groups of some proteins and inhibit their activity.
Results: During the research conducted, arsenic affects the function of a specific selenoprotein and increases the risk of developing diabetes. It also affects beta cells and metabolism and involves them until it causes changes in polymorphisms in Selenoprotein - and the difference in the DNA code of these proteins.
Conclusion: Today, scientists are investigating the medicinal activities of C. aromatica leaf extract, and the present experiment is planned for it. We hope these tests will give good answers.