• Cutaneous adverse reactions after COVID-19 vaccine: A Systematic Review
  • Ramtin Naderian,1 Negin Salehi,2,* Mohammad Forozeshfard,3
    1. Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran
    2. Student Research Committee, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    3. Cancer Research Center and Department of Anesthesiology, Semnan University of Medical Sciences, Semnan, Iran


  • Introduction: vaccine aversion, even to minor side effects (SEs), might raise vaccine hesitation at a time when mass vaccination is most needed. Mistrust in safety data provided by pharmaceutical corporations, according to the WHO's Strategic Advisory Group of Experts on Immunization (SAGE), may play a crucial role in diminishing vaccination acceptance levels. As a result, independent research on vaccine safety and SEs is a valuable asset in increasing public trust in COVID-19 vaccines and their efficacy. As a result, the goal of this systematic review was to collect cases of cutaneous SEs to COVID-19 vaccines in order to describe the timing and morphology of cutaneous SEs to COVID-19 vaccines and to understand differences in cutaneous SEs between the two vaccine doses in order to direct vaccine counselling.
  • Methods: The present study was conducted by systematic review. To access the Cutaneous adverse reactions after COVID-19 vaccine, articles indexed in databases Science Direct, PubMed, Scopus, Google scholar, web of science, Embase and Medline were used. Keywords including COVID-19; SARS-CoV-2; adverse event; vaccines; delayed inflammatory reaction; vaccine reaction; COVID-19 vaccine; cutaneous adverse reaction; COVID-19 skin; COVID-19 vaccination reaction; COVID-19 vaccine rash; coronavirus vaccine; vaccine allergy were searched over 2018 to 2021. According to the defined criteria, finally 66 Full text articles were reviewed in this study.
  • Results: The results of the present study showed that Pain, Tenderness Warmth, Itch, Redness, Swelling, rash and Herpes zoster are the most common. Additional less common reactions included Fatigue, headache, feverishness, and myalgia, Chills, Fever (¬38°C), Joint pain, Malaise, Muscle ache, Nausea, anaphylaxis, tachycardia, tachypnea and notable tongue swelling Lymphadenopathy (axillary or regional) and Arthritis. Reactions were more common after the first dose. Symptoms were more common near the injection site but were also seen in the neck, chest, lower back and face. Cutaneous adverse may occur immediately or even after 30 days.
  • Conclusion: cutaneous reactions to COVID-19 vaccination are typically minor and self-limited, and should not discourage vaccination. Allergic-type cutaneous symptoms, as well as efflorescence and angioedema, are transient and infrequently associated with anaphylaxis. However, more research into the side effect profile of COVID19 vaccines is required.
  • Keywords: COVID-19 vaccine, SARS-CoV-2, minor side effects, cutaneous adverse reactions, cutaneous reactions