• use of targeting peptides for cancer detection and drug delivery
  • fereshteh gholami,1,* Tara kanani,2 Amir Abbas Ansari,3 fatemeh soltanimoghadam,4
    1. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    2. Department of Medical, Lorestan of Medical Sciences, Lorestan, Iran
    3. Department of Medical, Jundi ShaporUniversity of Medical Sciences, Ahvaz , Iran
    4. Department of biology, Science and Arts University, Yazd, Iran


  • Introduction: The use of peptide and protein sequences in the treatment of cancer, as well as the transfer of drugs related to it, is a new method that has led researchers to focus their research from old treatment methods to the mentioned method. Surgery, as the first step in cancer treatment in the 19th century, cannot always be an effective way to completely remove cancer. Invasive tumors. Radiation therapy is another treatment that can extensively remove localized tumors and has been used since the 1960s. But it causes damage to normal tissues and even in combination with surgery, it cannot control metastatic disease. Intravenous cytotoxic chemotherapy has been the hallmark of medical cancer treatment for decades, targeting rapidly dividing cells. The main challenge of the pharmaceutical industry is its non-specific distribution. The use of chemotherapy drugs in the human body leads to acute toxicity against normal tissues with a higher proliferation rate, such as hair follicles, bone marrow, and digestive tissues, and thus limits treatment. Peptides have emerged as an attractive therapeutic tool due to their broad biological activity, high membrane permeability, and low manufacturing costs. new research has provided various therapeutic peptides, many of which are undergoing clinical trials.The current treatments against cancer are relatively good treatment methods, but the efficiency and the amount of risk that the patient faces in using these methods , It forces researchers to look for cheaper and more efficient methods and reduce the risk of treatment methods for the patient. This method is the strategy of using transporters such as nanoparticles, a method that due to their size and other physical and chemical properties are able to accumulate in tumors by passing through the gap in the endothelial cells covering the vascular wall. "Leaky" vessels around tumors for drug delivery is known as a permeability effect and represents a therapeutic modality.
  • Methods: This systematic study was mentioned using key words and referring to reliable scientific databases such as Scopus, PubMed, Google Scholar and ProQuest from the studies that were conducted until 2022 and a total of 16 articles were reviewed.
  • Results: Since 1988, two types of peptides have been discovered that have the ability to stimulate cells in the treatment process : peptide conjugation with nanoparticles and cell-penetrating peptides alone, those are the two cases. Short peptides increase the permeability of cells to the tumor . Cell-penetrating peptides can be converted into conjugated nanoparticles through short sequences of peptide linkers to create more functionality on polymeric nanoparticles, lipid nanoparticles or drug treatments.
  • Conclusion: Compared to proteins and antibodies, they are significantly less immunogenic and more stable at room temperature. Conjugation of cell-penetrating peptides with other nanoparticulate systems can enhance chemotherapy delivery. Additional advantages of using peptides as targeting agents include lower production costs, increased efficiency For the penetration of tumor masses, high stability and high adjustability. Target peptides, specificity Drug delivery systems to target tumors and cancer cells enhance absorption It increases drugs in cancer cells . Target peptides increase the specificity of drug delivery systems for targeting tumors and cancer cells, increase the absorption of drugs in cancer cells, and minimize the effects of the target.
  • Keywords: Peptides, neoplasms, drug delivery