• The association between ARNTL expression and metabolic syndrome
  • Atefeh Ebrahimi,1 Pedram Bolbolizadeh,2,* Zahra Kamyab,3
    1. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
    2. Student Research Committee, Faculty of Para Medicine, Hormozgan University of Medical Sciences, Bandar Abass, Iran.
    3. Student Research Committee, Faculty of Para Medicine, Hormozgan University of Medical Sciences, Bandar Abass, Iran.


  • Introduction: Due to the importance of early diagnosis and its effectiveness in the treatment of head and neck cancer, we identified and validated ten lncRNA as a biomarker for diagnosing head and neck cancer. The circadian clock, which is affected by fluctuating changes in the conditions of light, darkness, and temperature, is effective in all aspects of human life despite being independent of the sun. Many periodic and daily behaviors such as blood pressure and digestive activities that increase during peace or melatonin production in the evening are regulated and occur with food and sleep. This cell-independent oscillator, which exists in almost all cells of the body, is called the circadian clock. 4 This molecular clock is maintained by a master pacemaker that resides in it. The superior asthmatic nuclei (SCN) of the hypothalamus receive signals by the dawn-dusk light cycle, which pass through the photosensitive retinal ganglion cells (ipRGCs) and then are transmitted to the SCN by synaptic connections. Finally, the ling factor directs the transcriptional response mediated by per genes. Because exposure to light adjusts the SCN and the environmental clocks are synchronized with it when the geographical conditions change and the body travels, it takes approximately 24 hours to adapt to the new phase of darkness and light. Because the circadian clock is relatively stable against these extracellular changes and it is possible to match the physiological and behavioral hub cycle. Today, one of the biggest threats to our health, which every ethnic group and society is facing, is a sleep disorder, which more than 22 million Americans suffer from. Its many complications include major metabolic syndrome, arteriosclerosis, high blood pressure, dyslipidemia, obesity, diabetes mellitus, cardiovascular diseases, several cancers, and certain types of brain diseases such as Alzheimer's disease.
  • Methods: In this review, relevant studies were searched in scientific databases fusing Based on their title, keywords associated with ARNTL, metabolic syndrome and circadian clock from 2010 to march 2022. Out of 356studies, 27 articles related to our aim according to the inclusion criteria of this review article, were studied.
  • Results: Changes in circadian clock function have been linked to metabolic disorders in genome-wide association studies. Epidemiological studies have shown that a loss of nocturnal decline in blood pressure increases the risk of cardiovascular morbidity and mortality and end-organ damage. Looking at clock genes, however, there is no obvious association between symptoms of diabetes or metabolic syndrome and clock gene expression.
  • Conclusion: Studies clearly show that circadian disruption is important a risk factor for developing metabolic disorders, while obesity feedback and its Metabola-physiological consequences in circadian clock function in central and peripheral tissues, Creating a vicious cycle while cardiovascular complications like As high blood pressure is often seen in type 2 diabetes and in patients with metabolic syndrome, and circadian regulation disorder Rhythm in blood pressure regulation may or may not occur. This variety is another strong case for outpatient blood
  • Keywords: ARNTL, metabolic syndrome , circadian