• Application of Nano-Drug Delivery System based on nanoparticles in enhancing cancer treatment: A review
  • Zeinab mirzaei,1 Sudabeh Pourfadakari,2,* Zeinab Heydari,3 Fatemeh khaki,4 Alireza Qanbary,5 Amirhossein Parang,6
    1. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    2. The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    3. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    4. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    5. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    6. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran


  • Introduction: Cancer has now become one of the most important causes of death in the world. In the last two decades, more attention has been paid to the replacement of more effective and specific treatments with low side effects and more anticancer activity. One of these purification methods is the use of nanoparticles. Nano-drug delivery systems (NDDS) are drug-loaded functional nano-carriers with a diameter of 10 x 1000 nm and composed of various natural or synthetic materials that are used for targeted delivery and controlled release of therapeutic agents. In this abstract, we provide an overview of the recent application of nano delivery systems in the treatment of cancer.
  • Methods: In this review, 10 articles were selected using keyword search (Nano-Drug, Cancer, Tumor, Therapeutic Agents, Delivery System, and Chemotherapy) in databases such as Scopus, PubMed, and Google Scholar after reviewing relevant findings and evaluating data quality. All studies were conducted from 2016 until 2022 in the field of nano delivery systems and cancer.
  • Results: The focus of this review is on providing chemotherapy drugs with higher therapeutic efficiency. One of the most promising methods to develop a type of NDDS for cancer therapy is layer-by-layer assembly of a multilayer film on nanoparticles followed by optional pattern removal. Adverse events were promising for BIND_014, and the selection of patients with PSMA-positive CTCs before treatment is a promising strategy for targeted therapy of PSMA, which could have a therapeutic and toxic advantage over docetaxel-based chemotherapy.
  • Conclusion: Based on the research, LbL assembly technology can not only achieve the formation of homogeneous nanoparticles but also produce other heterogeneous NDDS with different components and complex structures such as multilayers. In addition, the thickness, the surface charge, and the morphology of the multilayers can be well controlled by adjusting the assembly conditions. Since the use of nanoparticles in strengthening immunotherapy, radiation therapy, and chemotherapy has resulted in more anti-cancer effects and common side effects, and the possibility of multimodal treatment has been provided, research on this subject is progressing rapidly. It can be hoped that with future research and developments, this method will be used in medical centers and a big step will be taken to improve patients' health.
  • Keywords: Nano Delivery System, Cancer therapy, Chemotherapy, Nanoparticles