• Globozoospermia genetics and its association with egg fertilization
  • elahe sadat mousavi,1,* Seyed Morteza Javadirad,2 Sadegh Valian Boroujani,3 Naser kalhorqom,4
    1. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
    2. Assistant Professor, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran. Orchid Code: 2293-2891-0002-0000.
    3. Professor, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
    4. Department of mesanchymal stem cell,Academic Center for Education,Culture and Research,Qom branch,IRAN.


  • Introduction: Today, fertility problems have become one of the major problems for young couples, so the study of genes involved in the emergence of abnormalities that lead to infertility in men and women is very important. globozoospermia is a severe sperm morphology abnormalities that lead to round head sperm. people with phenotype globozoospermia suffer from or completely lacking acrosome deficiency. due to the absence of acrosomic and round head sperm , the acrosomic reaction is impaired. to penetrate the sperm into the oocytes of the acrosomic enzymes, they begin to dissolve the plasma membrane, and the inner layer of the egg begins to liberate calcium granules and the The signaling cascade is launched. after the sperm penetrate the egg, the egg activation occurs.defects in each of these stages can lead to anomalies and infertility of the type of globozoospermia, and the article examines the genes involved in this process.
  • Methods: In this systematic review, the keywords of the globozoospermia, infertility, acrosome reaction, infertility treatment were found in Pubmed and Scholar Google and Scopus databases.
  • Results: Globozoospermia, including genes involved, can be mentioned Spata16, Pick1, GOPC, HRB, CSNK2A2 and DPY19L2. the mutation and removal in each of these genes can lead to globozoospermia. the expression of the Spaca1 gene is also reduced in globozoospermia. the expression level of the MRNA gene kifc1 was mainly observed in the testicles of patients with globozoospermia in the spermatide stage. the two SPATA16 and Pick1 genes play an important role in the Spermatogenesis process, as the Spata16 protein plays a role in organizing the Golgi and acrosomic granules organized in rounded and elongated spermatozoa. and Pick1 can adjust the transportation of the Golgi Network vesicles to the endoplasmic network. in fact, Pick1 is involved in the transmission of vesicles from Golgi to the acrosome and collaborates with GOPC and CSNK2A2 in the construction of acrosome, although no globozoosperm man has been found to carry a mutation in the GOPC or CSNK2A2 gene, some of the cases of human globozoospermia are likely to be explained in these two genes. anyoploid levels, especially in chromosomes 1, 13, 15, 16, 21, XX and YY in sperm, are also significantly higher than a normal person.
  • Conclusion: Therefore, Spa16, Pick1, GOPC, HRB, CSNK2A2, KIFC1, Spaca1 and DPY19L2 genes are among the genes involved in the incidence of globozoospermia and aneuploid rate in chromosomes 1, 13, 15, 16, 21, XX and YY in sperm Patients with globozoospermia are also significantly higher than a normal person.
  • Keywords: Globozoospermia, Infertility, Acrosome Reaction