• Evaluation of the effects of high-intensity resistance training in patients with osteosarcopenia: as a way to prevent and improve complications
  • Mohammad Mehdi Khaleghi,1,* Reza Ghiasvand,2 Maryam Kamrava,3 Zahra Talkhabi,4 Maryam Nourshargh,5 Erfaneh Shabnifard,6
    1. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    2. Nutrition Department of Community Nutrition School of Nutrition and Food Sciences Isfahan University of Medical Sciences
    3. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    4. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    5. Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
    6. Student Research Committee, Bushehr University of Medical Sciences, Bushehr, Iran


  • Introduction: Osteosarcopenia is the simultaneous degeneration of skeletal muscle, decrease in muscle function, and loss of bone mass due to aging or low physical activity. The adverse consequences associated with it, including fractures, falls, increase in risk of insulin resistance and metabolic syndrome, depression, and loss of independence and even the risk of death, necessitate interventions against it. The purpose of this article is to evaluate resistance training as a strategy to stimulate the skeletal response and prevention the reduction of muscle mass in order to combat osteosarcopenia.
  • Methods: Information sources were searched in google scholar, PubMed and Scopus databases since 2017 using related keywords; Resistance training, Osteosarcopenia, HI-RT, high-intensity resistance training. Finally, the most relevant articles were examined.
  • Results: The results of this article are about the improve body composition such as significant optimize in MetS Z-score, Waist circumference and HDL-C and moderate arterial blood pressure; significant increase in maximum strength, maximum hip and leg extensor strength, Habitual gait velocity, LBM and SMI; and remarkable decrease in Total body fat mass, abdominal body fat percentage and Areal BMD at the total hip ROI. On the other hand, a slight improvement in osteoporosis markers and Handgrip strength maintained was also seen. They all leads improve a person's functional capacity.
  • Conclusion: The research works mainly focuses on reducing the social and economic costs of osteosarcopenia by improving the physical condition of the elderly. Although current drug therapies for osteoporosis have no effect on muscle mass, there is strong evidence that resistance exercise, along with a balanced diet, can have a dual effect on bone and muscle, all of which help improve function. Since there are many interactions between muscle and bone, additional research can be done to better understand these interactions, which will help facilitate the development of new therapeutic agents.
  • Keywords: Resistance training, Osteosarcopenia, HI-RT, high-intensity resistance training