Analysis of solvent effects on collagen nanofibers
Analysis of solvent effects on collagen nanofibers
Tahereh Mehrvarz,1,*Dr. Abbas Parham,2Kaka GholamReza,3Mahdavi Hamid,4
1. ferdowsi university of mashhad 2. ferdowsi university of mashhad 3. Baqiyatallah University of Medical Sciences, Tehran ,Iran 4. Iran Polymer and Petrochemical Institute,Tehran,Iran
Introduction: introduction: Tissue repair refers to the replacement of damaged parts by living cells including mimicking the extracellular environment as the natural niche of the cell for tissue regeneration, which increases adhesion and cell growth. Collagen is a key component of the extracellular matrix. Its characteristics include its nature in reconstruction and restoration and the dimensions of the resulting fibers, and the degree of porosity and high bonding strength. In addition to the molecular weight of the polymer, which affects its viscosity, the type of solvent should also be considered.
Methods: In this research, articles between 2012 and 2022 were selected from Science Direct and Scopus, which were screened after identifying the articles.
Results: In the conducted research, there is a direct relationship between the type of solvent and the diameter of the fibers. In research that used acetic acid and DMSO. It was from nanofibers with a diameter of 200to 639 nm. In another study, hexafluoropropylene HFP trifluoroacetic acid TFA was used and the fiber diameter was reported between 220 and 415. In a similar study, the weight percentage of polyvinyl alcohol was used along with collagen, which according to the feeding rate
Between 0.02 and 0.1 and 0.3, the diameter of the formed fibers was 90 to 240 nm
Conclusion: The modeling and arrangement of nanofibers, it has a lot to do with the type of solvent. Among these, properties such as dielectric constant, surface tension, and even output flow rate are also important. And due to the fact that some solvents are toxic, they can cause a change in the structure of nanofibers and the nature of the fibers. Therefore, it seems that the choice of solvent and mixing material is very important. Probable strategies can be based on error testing, but according to numerical calculations and in order to reduce the number of tests, computational analysis can be used.