The role of stem cells in the occurrence of cancer
The role of stem cells in the occurrence of cancer
sogol ebrahimpour,1,*
1. . Bachelor of Microbiology, Department of Biology, Qods City Branch, Islamic Azad University, Tehran, Iran.
Introduction: Introduction and aim: A group of proliferating cells with high power and great treatment resistance, known as CSCs, are the primary cause of cancer. The purpose of this review is to examine the part stem cells play in the development of cancer.
Methods: Search Method: The current study, which looked through academic databases like Google Scholar, Science Direct, Springer, and PubMed, examined the part that stem cells play in the development of cancer.
Results: Result: The CSCs might be made to adapt to various settings. According to research, the strong proliferative potential with a loss of a normal differentiation program and great efficiency in response to environmental changes determine the CSC self-renewal potential. The proliferative and quiescent states, which are distinguished by symmetric and asymmetric cell divisions, are the two primary phenotypes of CSCs. The primary cause of metastasis that would develop years after surgical removal of a primary tumor may be CSCs with a quiescent phenotype.
Conclusion: Conclusion: It can be deduced that chemotherapy would kill tumor cells without the CSC marker, causing the tumor to retreat, while the CSC-positive cells are resistant to the medication and their number would increase in the tumor. Quiescence, enhanced production of anti-apoptotic proteins, expression of ABC (ATP-binding cassette) drug pumps, and resistance to DNA damaging agents are all ways to protect CSCs from therapeutic agents and boost their resistance to the therapeutic process.