Introduction: apoptosis is programmed cell death that occurs in multicellular.BCL-2 protein as a proteo-oncogene in germ cells is involved in the regulation of cell apoptosis.This protein generally plays a role in inhibiting cell apoptosis.Ativan (Lorazepam) ischemically a short-acting anti-anxiety drug that belongs to a group of drugs called benzodiazepines.The purpose of thisresearch is to investigate the effect of Ativan (lorazepam) on BCL-2 protein.
Methods: This research was carried out by descriptive-analytical method. Chimera 1.10.2 and PyRx programs were used in this research, as well as Uniprot,Pubchem,PDB,Pubmed,drugs and Deepsite site.
Results: We started the analysis and the following results were obtained.
Binding affinity 1: _7.5
Binding affinity 2: _7.1
Binding affinity 3: _7.0
Binding affinity 4: _7.0
Binding affinity 5: _6.9
Binding affinity 6: _6.8
Binding affinity 7: _6.8
Binding affinity 8: _6.7
Binding affinity 9: _6.6
Conclusion: The obtained results indicate that Ativan drug has a good effect on BCL-2 protein and in the near future this drug can be used to regulate BCL-2 protein and control it.
Keywords: Apoptosis , BCL_2 protein , Ativa, Lorazepam