Stem cells as carriers for oncolytic viruses in treatment of cancer
Stem cells as carriers for oncolytic viruses in treatment of cancer
Piruz Shadbash,1Seyed Reza Mohebbi,2,*Seyed Masoud Hosseini,3Shahnaz Mohammadi,4Mohammad Reza Zali,5
1. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2. Research Center for Gastroenterology and Liver Diseases, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3. Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran 4. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran 5. Research Center for Gastroenterology and Liver Diseases, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Introduction: Oncolytic viruses (OV) are considered as a novel class of anti-cancer agents due to their selective ability to infect and destroy cancer cells.
Methods: Currently, the most common way of delivering OV is intratumoral to target metastatic diseases and tumors. The effective methods for the systemic delivery of OVs, is like the use of carrier cells.
Results: Due to the specific migration capacity of stem cells, they can be used as carriers or vectors targeting metastatic cancers.
Conclusion: Promising results have been reported in the use of stem cells and oncolytic viruses as a therapeutic approach to the treatment of metastatic cancer.
Keywords: Oncolytic viruses, carrier cells, stem cells, metastatic cancer