Introduction: The use of bacteria for the synthesis of nanoparticles has many advantages, including the high compatibility of nanoparticles with the environment and the ability to produce them on an industrial scale. Green synthesis is a simple and fast method and has recently received much attention. Iron oxide nanoparticles are physically and chemically stable and safe. Brevibacterium Casei is one of the microorganisms capable of producing nanoparticles. Folate receptors, which are expressed in different types of cancer cells, can be used in targeted treatments for cancer. Nanoparticles conjugated with folic acid can help in targeted delivery of drugs used in brain cancer and crossing the blood-brain barrier.
Methods: In this synthesis method, after bacterial culture, the suspension is combined with iron nitrate solution and iron nanoparticles are synthesized. After the conjugation of nanoparticles with folate and drugs, its experimental effects can be investigated and observed in cancer cells.
Results: Metal nanoparticles produced by the green method from microorganisms are promising compounds for future biomedical research. Nanoparticles produced by this method, besides being safe and highly biocompatible, also have the capability of mass production and can be more economical than other methods.
Conclusion: Traditional methods such as radiotherapy and chemotherapy as well as conventional drugs have been ineffective for the treatment of brain cancer. Using nanoparticles produced from microorganisms for targeted drug delivery in cancer treatment can be a new perspective for drug design in the future.
Keywords: green synthesis, folate receptor, blood brain barrier