• The effect of stem cells in the treatment of intestinal lymphoma
  • Elina Fekri,1,* Fatemeh Jabbari,2
    1. Student research Center, Baharestan 1 Education Office, Baharestan 1, Tehran, Iran
    2. Student Research Center, Education Office, Baharestan 1, Tehran, Iran


  • Introduction: Intestinal lymphoma cancer is one of the common cancers in our country, which has a relatively high prevalence. This disease is an aggressive disease that is currently treated with a combination of chemotherapy and surgery. Forty percent of lymphomas occur in areas other than lymph nodes, and the digestive system is the most common. Stem cells are cells which have high ability to divide and differentiate, and in response to specific stimuli can differentiate into different types of cells in the body. By using stem cells, it is possible to prevent the spread of intestinal lymphoma and complications caused by chemotherapy (anemia, infertility, respiratory and kidney problems, risk of infection, etc.) and surgery.
  • Methods: Bone marrow stem cells, fetal umbilical cord blood stem cells, and peripheral blood stem cells are important sources to obtain stem cells.
  • Results: New studies on gastrointestinal lymphoma in the intestine suggest a solution to destroy and destroy cancer cells using chemotherapy and then using stem cells. The given solution is that after knowing the type of cell involved in cancer and finding the center of this cell, the protein gene that controls the proliferation of cancer is placed in the stem cell (umbilical cord blood stem cell, fat stem cell, etc.) and then enter the place of accumulation of lymphoma. In this case, the stem cell surrounds the cancer cell and there is no opening left for the cancer cell to metastasize. It is also possible to add a type of Grb2 protein to the stem cell to control cell proliferation. In this case, the cancer cell, which is trying to escape from this stem cell protection, becomes weak, and at this time, the use of low doses of medicine is enough to destroy it. In addition, there is no need for surgery and the long-term use of chemotherapy drugs, and the healthy cells around the cancer cell also remain healthy.
  • Conclusion: This method, that is, the treatment of cancer cells using stem cell transplantation, can be used in the treatment of gastrointestinal lymphomas, including intestinal lymphoma. For this, we need multipotent stem cells that can be taken from the individual or preferably donated cells. It seems that using this method to treat intestinal lymphoma can treat lymphoma at any stage.
  • Keywords: Keywords: Stem cell, Intestinal lymphoma, Cancer