Environmental toxins and the impact of other endocrine disrupting chemicals in women's reproductive health
Environmental toxins and the impact of other endocrine disrupting chemicals in women's reproductive health
Fatemeh Govahi Kakhki,1Maryam Vafadar,2Negar Jahanbazi,3Elaheh Oliyaei,4,*
1. Dept of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran 2. Dentistry, school of dentistry, Tehran University of medical science, Tehran, Iran 3. Dept of Speech And Language Pathology,School of Medicine,Ahvaz University of Medical Sciences, Ahvaz, Iran 4. Faculty of Paramedicine, Department of medicine, Bushehr University of Medical Science, Bushehr, Iran
Introduction: Human fertility is decreasing anywhere withinside the world, and one in every of the critical motives is the accumulation of environmental pollution with interior our bodies of men and women. Therefore, this systematic evaluation has grown to be done at the effects of environmental pollution and one of a type endocrine disrupting chemical substances on women's reproductive health.
Methods: In the forthcoming systematic study, the required data were collected using keywords and citing valid databases such as: Scopus PubMed, Google Scholar and ProQuest. The statistical population of the study includes all studies conducted up to 2022 in the field of Environmental toxins and the impact of other endocrine disrupting chemicals in women's reproductive health. After reviewing the relevant findings and evaluating the data quality, a total of 20 articles were analyzed.
Results: Various research have established that the principal corporations of chemical substances that cause toxicity with in the reproductive tool are: solvents, asbestos, silica, metals together with chromium, lead and mercury, hair dyes and beauty products, persistent natural pollution and insecticides, smoking, endocrine disruptors chemical substances such as, tetrabromobisphenol A, bisphenol A, bisphenols F and S and bisphenol B. The worst productiveness disrupters are organochlorine compounds (dioxins, polychlorinatedbiphenyls, and chlorinated insecticides), bisphenol A (BPA), herbicides and organophosphate insecticides. Human exposure to environmental chemical substances is related to lengthy time period outcomes and acute toxicity, together with, cognitive disabilities, cancer, continual diseases, start defects, death, and has the cap capacity to be transmitted to the following generation. In addition, disruption of women's reproductive characteristic through way of endocrine disrupting chemical substances might also additionally moreover furthermore result in lack of ovulation, beside the issue of hormone production, menstrual cycle disorders, infertility, and untimely growing older of fertility. Experimental statistics show that publicity to insecticides has a terrible impact on the cap capacity of the ovary to provide intercourse hormones in animal fashions and women. By developing the amount of hexachlorocyclohexane, polychlorinated biphenyls and dichlorodiphenyltrichloroethane withinside the blood of women, their fertility decreases. Women with the very awesome stages of polychlorinated biphenyls have an extreme 50% reduce charge in their cap capacity to get pregnant. Several insecticides together with malathion chlorpyrifos, endosulfan, and permethrin cause ovarian abnormalities after start, lower withinside the big variety of follicles, and decorate follicular atresia. While the increase withinside the degree of chlorinated bisphenols have grown to be related to a Lesser in inconvenient situations and fertilization charge for oocyte increase. No vast correlation has grown to be decided among polychlorinated biphenyls interest and its cap capacity to sell fibroid development. Epidemiological research rarely has investigated the affiliation among heavy metallic publicity and reproductive effects. Some researchers noted an affiliation among blood lead degree and infertility.
Conclusion: Extensive publicity to quite a few of notable chemical substances has brought on several abnormalities withinside the girl’s reproductive tool and numerous animal species. Reproductive effects might also additionally moreover furthermore be dose-based and associated with lengthy-time period publicity and the interest degree of the compound present. Most to be had statistics deliver a lift to the proof for women's reproductive health-associated sports activities, sports of endocrine disrupting chemical substances. However, the actual mechanisms that cause the physiological, molecular changes and cellular aren't clear. In the future, guidelines ought to be made to lower human publicity to endocrine disrupting chemical substances and defend reproductive health.