Endothelial cell derived microparticles as prognostic biomarker in multiple sclerosis
Endothelial cell derived microparticles as prognostic biomarker in multiple sclerosis
Dorsa Gharehghooni,1Soha Azizi,2Akbar Hashemi Tayer,3,*
1. Student research committee, Jahrom University of Medical Sciences, Jahrom, Iran 2. Student research committee, Jahrom University of Medical Sciences, Jahrom, Iran 3. Research Center for Non-communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran
Introduction: Microparticles (MPs) are submicron cell membrane derived fragments that increased in many physiological conditions like apoptosis or pathological conditions such as multiple sclerosis (MS) and many other diseases. MPs play a significant role in physiological processes such as inflammation, coagulation, and vascular function.
Methods: A systematic search was performed to identify studies published in multiple databases (sciencedirect, PubMed, ProQuest, Cochrane and google Scholar) up to 2022, and recently published abstracts were also reviewed. Using the key words such as MS, microparticles and endothelial.
Results: Increased Endothelial cell derived MPs (EnMPs) counts have been reported in MS. of the cerebral endothelial cells. EnMPs express different markers at their level. Expression of markers such as CD62E shows activated endothelial cells. Overproduction of microparticles in cerebrospinal fluid (CSF) has been reported in many patients, and these particles might be one of the major factor in the development of MS. Drugs used to treat MS, such as interferons, reduce the release of a number of EnMPs. Therefore, it is likely that EnMPs can be used as a functional and sensitive biomarker for the diagnosis and prognosis of the MS.
Conclusion: Endothelial dysfunction is evident in the incidence and exacerbation of MS. Prompt diagnosis and timely treatment can be very helpful. It is hoped that this will be possible by further understanding the EnMPs and their function.