Evaluation of frequency of cagA gene from Helicobacter pylori in patients with myocardial infarction
Evaluation of frequency of cagA gene from Helicobacter pylori in patients with myocardial infarction
Saber Basiri,1,*Hussein Rasi,2Behin Omidi,3
1. Department of Biology, Faculty of Basic Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran. 2. Department of Microbiology, Faculty of Basic Science, Karaj Branch, Islamic Azad University, Karaj, Iran. 3. Department of Biology, Faculty of Basic Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Introduction: Cardiovascular disease is one of the most important causes of death in industrial and developing countries, including Iran. Several studies have reported the association between chronic infections such as Helicobacter pylori and cardiovascular events. This research aimed to Evaluate the frequency of cagA gene from Helicobacter pylori in patients with myocardial infarction and its association with cardiovascular diseases as a risk factor. The result of this study can be significant in the timely diagnosis and treatment of cardiovascular diseases.
Methods: In this study, 194 patients with cardiovascular diseases were examined with intravenous blood, all obtained using standard techniques, and the rate of serum cholesterol, LDL, HDL, triglyceride, cardiac Enzyme, troponin, and IgG serum of each patient was measured by biochemistry Auto analyzer and ELISA system. Then DNA was extracted from samples, and the frequency of genes of the cagA, the gene was determined from H.Pylori in the patient via PCR, and then compared with Epiinfo software.
Results: Among 194 patients, cagA gene in 129 cases was positive (66/49%). Finally, comparing the biochemical parameters of the patients in both groups with positive cagA and negative cagA showed a significant difference in the rate of triglyceride, cholesterol, HDL-C, LDL-C, and AST between the two groups.
Conclusion: Additionally, the presence of cagA can increase the risk of affection for cardiovascular disease, especially in people under 50 years old.