potential inhibitory effect of lycopene on prostate cancer
potential inhibitory effect of lycopene on prostate cancer
mostafa roozbahani,1mohammadreza gallehgiryan,2Fatemeh Beilari,3sahar jafari,4pouya ghaderi,5,*
1. student research committee, Lorestan university of Medical Sciences, khorramabad , Iran. 2. student Research and technology committee Bushehr university of Medical sciences, Bushehr , Iran. 3. hamadan university of medical sciences 4. gorgan university of medical sciences 5. Intership, student of medicine, school of Medicine , Mashhad Islamic Azad university of Medical Scienses, Mashhad, Iran
Introduction: Prostate cancer (PCa) is one of the most common urological malignancies in adult men. There are several risk factors such as genetics and environment for PCa. Nutrition plays an important role in causing cancer. Lycopene is a bright red carotenoid hydrocarbon found in red vegetables (such as red carrots), some fruits (such as tomatoes). In addition, dietary lycopene was associated with a reduced risk of PCa. Therefore, the important role of lycopene has made it necessary to develop it as a therapeutic agent for PCa. There is still no conclusive evidence to support an anti-cancer effect. The aim of this research is to investigate the potential effect of lycopene on prostate cancer
Methods: In this systematic review, we collected the data we needed by using keywords and also by referring to reliable databases such as PubMed, Scopus, google scholar and ProQuest. The statistical population of this study includes all studies conducted until 2022 after reviewing relevant findings and evaluating data quality, we analyzed 15 articles
Results: Most studies have shown that lycopene inhibits cell proliferation, stops the cell cycle at different stages, and increases apoptosis in human PCa cell lines. Several studies have shown that lycopene have no significant effect on PSA levels. Due to the limited number of available studies, there is heterogeneity regarding the source and dose of lycopene, participants' health status, baseline PSA, and circulating lycopene. Some studies have shown that consumption of canned and cooked tomato-based products is inversely associated with prostate cancer risk, but the association between prostate cancer risk and raw tomatoes, were not statistically significant.
Conclusion: In conclusion, the present study supports the suggestion that lycopene extracted from food products may have a protective effect on PCa. These findings further support current dietary recommendations to increase intake of dietary sources of lycopene to reduce prostate cancer risk