The Importance of SOMAscan in Investigating Serum Biomarkers
The Importance of SOMAscan in Investigating Serum Biomarkers
Nima Naseri,1,*
1. Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Introduction: The power to assess people with different abnormalities and, more specifically, those most noteworthy hazard adverse health outcomes remains a vital neglected requirement in most ailments. So that a perfect solution should involve a test, such as a blood sample test, that can specifically be conducted in a primary care setting. In this manner, a population of interest, as they are most likely to advantage from effective mediations. The proteomic analysis allows the simultaneous assessment of numerous proteins within a biological sample. The SOMAscan proteomics approach was utilized to recognize biomarkers that differentiate disease stages, in a population of patients with multiple abnormalities.
Methods: We selected the characteristic SOMAscan keyword from Mesh in NCBI. Then we search SOMAscan in Scopus and PubMed databases to publish a specific subject about SOMAscan. Assay. In the following, the gained and related articles are summarized and discussed.
Results: The SOMAscan method was used to quantify the expression of more thousand proteins biomarkers in each serum sample. SOMAscan information underwent quality control and transformation based on bioinformatics standards. SOMAscan involves a specific protein measurement system using Slow Off-Rate Modified Aptamer (SOMAmer) molecules that bind to proteins with high affinity and specificity.
Conclusion: SOMAscan has been used to identify diagnostic signatures of Serum Proteins Associated With multiple diseases, Biomarker Clustering Analysis, Hormonal Pathways Dysregulation in Patients, and Machine Learning.