Correlation of adiponectin/leptin ratio with infertility and abortion in Iranian women with polycystic ovary syndrome
Correlation of adiponectin/leptin ratio with infertility and abortion in Iranian women with polycystic ovary syndrome
Asma Kheirollahi,1,*
1. Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Introduction: Adiponectin and leptin are two adipocyte-derived hormones that modulate the hypothalamic–pituitary–ovarian axis functions. Considering the opposite effects of leptin and adiponectin on different biological processes, the adiponectin/leptin ratio has been introduced as an emerging biomarker, and recent studies highlight its correlation with BMI, obesity, metabolic syndrome, insulin resistance, insulin levels, coronary artery disease, and stroke in different populations in Europe and Asia. This study aimed to assess the correlation of adiponectin/leptin ratio with infertility and abortion in Iranian women with PCOS.
Methods: A data set of 127 women with PCOS (including 57 infertile patients and 70 patients with a history of recurrent abortion) and 37 healthy control was enrolled in this study. Leptin and adiponectin were measured by ELISA kits.
Results: Our results showed that with every 0.01 unit increase in adiponectin/leptin ratio, the chance of infertility decreases by 18%. Also, each 0.001 unit increase in adiponectin/leptin ratio could decrease the chance of abortion by 18% in PCOS women.
Conclusion: The results of this study showed that the adiponectin/leptin ratio is correlated with a decreased risk of infertility and abortion in PCOS patients.