Correlation of HOMA-IR/Adiponectin ratio with infertility and abortion in Iranian women with polycystic ovary syndrome
Correlation of HOMA-IR/Adiponectin ratio with infertility and abortion in Iranian women with polycystic ovary syndrome
Asma Kheirollahi,1,*
1. Department of Comparative Biosciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Introduction: PCOS is a common endocrine-metabolic disorder in women of reproductive age. The association of abnormal adiponectin levels and insulin resistance with PCOS was observed in several investigations. Recently, some studies introduced the HOMA-IR/Adiponectin ratio as a biomarker of metabolic syndrome. The aim of this study was to assess the correlation of the HOMA-IR/Adiponectin ratio with infertility and abortion in Iranian women with PCOS.
Methods: A data set of 144 women with PCOS (including 57 infertile patients and 70 patients with a history of recurrent abortion) and 50 healthy control was enrolled in this study. Adiponectin levels were measured by ELISA kits. Homeostasis model assessment of adiponectin (HOMA-Adiponectin) was calculated using the following formula: fasting insulin (μU/L) × fasting glucose (mmol/l)/22.5.
Results: Our results showed that with every 0.01 unit increase in HOMA-IR/Adiponectin ratio, the chance of infertility increases by 7%. Also, each 0.001 unit increase in adiponectin/leptin ratio could increase the chance of abortion by 6% in PCOS women.
Conclusion: The results of this study showed that the HOMA-IR/Adiponectin ratio is correlated with an increased risk of infertility and abortion in PCOS patients.