• Comparison check The effect of drugs novantrone(Mitoxantrone) & prozak (Fluoxetine) on protein MBP by molecular docking method
  • Negin Bakiasay,1,* Sahel Delavari,2
    1. animal Biology tehran eslamic azad university of medical Science
    2. Cellular and Molecular Biology tehran eslamic azad university of medical Science


  • Introduction: Protein information:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system. MBP maintains the correct structure of myelin, interacting with the lipids in the myelin membrane. MBP was initially sequenced in 1971 after isolation from bovine myelin membranes. Drug information :novantrone(Mitoxantrone): Mitoxantrone for the treatment of leukemia and other cancers It is also used to treat multiple sclerosis (MS). This drug is known as a group of drugs that They are known as anthracandiones and they slow down or stop the growth of certain cells (including cancer cells and cells that affect the body's natural defenses). prozak (Fluoxetine): Fluoxetine is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class . It is used for the treatment of major depressive disorder, obsessive–compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. The scope of this work is much more than the mentioned materials.The purpose of this project is to compare the effects of novantrone(mitoxantrone) and prozak(fluoxetine)on mbp protein.
  • Methods: Doking articles are done in a descriptive_analytical way. Pyrx and chimera’s applications are used in this article .First , we searched for the desired protein through the uniport site , then we choosed its human sample and searched for its molecular form it gave us a variety of protein samples , we choosed a sample that has fewer chain and it has more initial and terminal nucleotides then we saved the protein file in pdb format . We searched for the drug we want (novantrone /prozak) through the pubchem site then saved its three-dimensional structure in sdf format. To do the docking process with the chimera program we removed the extra chains , water molecules and ions and we added hydrogen . finally , we performed the process on chain ( a ) . we saved the final file in pdb format.
  • Results: According to the docking results of the drug effect preozak(Fluoxetine) on protein MBP Compared to drugs novantrone(Mitoxantrone) It is better.
  • Conclusion: According to the docking results of the drug effect preozak(Fluoxetine) on protein MBP Compared to drugs novantrone(Mitoxantrone) It is better.
  • Keywords: MBP protein, novantrone(Mitoxantrone), prozak (Fluoxetine), MS disease, Molecular docking