Introduction: Deltamethrin (DM) as one of the most
widely used agricultural pesticides, is one
of the environmental factors that can have
destructive effects on the male fertility.
According to studies, folic acid is one of the
effective factors in increasing the quality of
male fertility.
Methods: In this experimental study, 25 adult NMRI
male mice were divided in to five groups
(n=5/each). The control group received only
normal saline. Sham received 0.2 ml corn
oil. Folic acid group 0.08 mg/kg, DM group
0.6 mg/kg and DM+FA group received both
of them. After 28 days of treatment, the
mice were anesthetized and blood samples
were taken from the heart to extract serum.
The mice were then operated on and the left
tail of the epididymis was removed to
extract adult sperm. Hormonal analysis was
performed by ELISA and CL methods.
Results: The results showed that in DM group
sperm count, motility, testosterone and free
testosterone significantly decreased.
(p<0.001) treatment with FA in the DMtreated mice significantly improved these changes.
Conclusion: With these findings it was concluded that
folic acid can protect against deltamethrininduced damage and improve epididymal
sperm parameters and increase fertility in
male mice.