Application of BAM15 as a fat-burning molecule in the treatment of obesity and related disorders
Application of BAM15 as a fat-burning molecule in the treatment of obesity and related disorders
Reyhaneh Sajed,1Ali-Asghar Karkhanei,2,*
1. Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. 2. Department of Industrial and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
Introduction: Obesity is the source of various diseases in the world. More than 650 million people worldwide are obese. Many genetic and environmental factors, including: basal metabolism rate, satiety, hormonal function, movement activities and nutrition, provide the basis for obesity. There are currently only a few treatments for obesity, and people who take these drugs are usually able to lose weight over a long period. Treatment of obesity requires new and standard drugs. This new research is a very effective step in the drug discovery process. Recently, a molecule called BAM15 has been discovered that reduces weight by increasing body metabolism without affecting the amount of food eaten, muscle mass, increased body temperature, or toxic biochemical and hematological markers. BAM 15 as an uncoupler reduce the production of ROS, and as a result, by reducing inflammation and oxidative stress, they can treat disorders related to mitochondrial oxidative stress, including ischemic damage, Parkinson's disease, Alzheimer's, insulin resistance, aging, heart failure, sepsis, Non-alcoholic fatty liver disease, cancer, and have a favorable effect on disorders such as obesity that benefit from increased energy consumption.
Methods: In vitro studies, using different concentrations of Bam-15, the effect of this molecule on factors such as glucose absorption, fatty acid uptake, and the expression of genes involved in metabolic pathways were investigated. Body temperature, body weight, and daily food intake were also measured in Bam 15-treated mice.
Results: Bam 15 stimulates insulin signaling and glucose and fatty acid uptake in an AMPK-dependent manner. It also limited the expansion of fat in the liver and kidney in C57BL/6J mice, thereby preventing diet-induced obesity while improving glycemic control.
Conclusion: Collectively, the studies show that pharmacological mitochondrial isolation with BAM15 has powerful anti-obesity and related disease effects.