• The effect of vitamin C supplements on sperm health
  • elahe sadat mousavi,1,* Seyed Morteza Javadirad,2
    1. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.


  • Introduction: Sperm health is very effective in male fertility, and therefore changes in concentration, morphology, and sperm mobility can cause infertility in men. Diet, environment and genetics, and the production of intracellular oxygen species (ROS) can change sperm factors and affect sperm generation and quality.the imbalance between ROS levels and physiological antioxidants can lead to oxidative stress, and oxidative stress is one of the main causes of reproductive failure .scorbic acid, best known as vitamin C, is the most important semen antioxidant and 65 % of the semen's antioxidant capacity belongs to this vitamin.
  • Methods: In this systematic review, the PubMed and Google Scholar and Scopus database reviewed the key words used in this study were sperm, vitamin C and infertility.
  • Results: Oral administration of Vitamin C is associated with a daily basis with increasing level of expression of the Protamine gene in men. vitamin C therapy In addition to improving sperm properties and DNA integrity, the MRNA level of Protamine 1 (PRM1), Protamine 2 (PRM2), as well as the Prm1/PRM2 ratio.treatment with vitamin C supplements increases sperm count, sperm analysis improves and fertility increases. Therefore, higher doses of vitamin C may be helpful in the treatment of infertility. Increasing the dose of vitamin C to 1000 mg daily also significantly improves sperm properties in smokers. Vitamin C, in addition to enhancing sperm quality, prevents its accumulation and increases sperm motility.
  • Conclusion: In this study, the positive effect of vitamin C on sperm functional properties examined. We believe that these results are of high scientific value for future research. Based on these findings, we found that further studies are needed to evaluate the effect of vitamins and minerals on sperm properties, so that supplements can be used as therapeutic recommendations in the treatment of male infertility.
  • Keywords: sperm, vitamin C, male fertility, antioxidant