Therapeutic effects of adipose-derived mesenchymal stem cells on gentamicin-induced renal failure
Therapeutic effects of adipose-derived mesenchymal stem cells on gentamicin-induced renal failure
Leila Hafazeh,1,*Saeed Changizi-Ashtiyani,2
1. Department of Physiology,Tehran medical University of Medical Sciences, Tehran, Iran 2. Department of Physiology, Arak University of Medical Sciences, Arak, Iran
Introduction: Considering the limitations of conventional therapeutic methods in
renal failure, researchers are paying attention to the application of adipose-derived
mesenchymal stem cells (AD-MSCs) and their protective effects against acute renal
failure. This study aims to assess the therapeutic effects of AD-MSCs in
gentamicin-induced renal failure in rats
Methods: In this study, fourty male Wistar rats were studied in control, sham, gentamicin
treated with and without receiving AD-MSCs. After ten days, blood samples were
collected and hemodynamic parameters, malondialdehyde and ferric reducing
antioxidant power (FRAP) measured in the right and left kidneys underwent histologic
examination
Results: Gentamicin administration significantly increased plasma creatinine, blood
urea nitrogen, oxidative stress parameters and histologic damages; while significantly
reduced FRAP in the gentamicin-receiving group in comparison with the sham group.
AD-MSCs treatment significantly improved renal function parameters, oxidative stress
and histologic damages in comparison with the gentamicin receiving group.
Conclusion: Intravenous injection of AD-MSCs in gentamicin-induced renal failure
improved renal function, oxidative stress parameters and histologic damages.