Evaluation of coagulation parameters in COVID-19 patients with diabetes
Evaluation of coagulation parameters in COVID-19 patients with diabetes
Niloofar Honari,1Forouzan Karam,2Saeedeh Dadi,3Ahmad Moradi Poodeh,4Mojtaba Poresmailli Ravari,5Gholamreza Anani Sarab,6,*
1. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. 2. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. 3. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. 4. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. 5. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran. 6. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Introduction: Diabetes is the most common comorbid disease in patients with Covid-19 which leads to adverse clinical outcomes. On the other hand, coagulation disorders in Covid-19 patients are a major problem associated with high mortality. The aim of this study was to evaluate coagulation parameters in Covid-19 patients with diabetes.
Methods: A systematic search was performed using related keywords such as "COVID-19", "SARS-COV-2", "Diabetes", and "Coagulation parameters" in Pubmed, ScienceDirect, and Google Scholar databases from 2020 to 2022. In this study, 15 articles including original and observational articles were used.
Results: In diabetic patients with Covid-19, levels of D-Dimer, IL-6, C-reactive protein (CRP), and ferritin were significantly increased compared to non-diabetic patients with coronavirus. However, no significant differences were observed in platelet count, prothrombin time (PT), and relative thromboplastin time (PTT). In some studies, fibrinogen levels showed a significant increase, while in others, the increase was not significant.
Conclusion: In general, diabetic patients are at significant risk of coagulopathy and thromboembolism if they develop coronavirus disease, and even these risks can lead to mortality in these patients. Consequently, the evaluation of routine coagulation tests, especially D-Dimer, which is related to the prognosis of the disease, should be performed periodically and regularly in diabetic patients with Covid-19 and, if necessary, preventive measures should be taken.