Clinical application of Stem Cell Therapy in rheumatic diseases
Clinical application of Stem Cell Therapy in rheumatic diseases
Narjes Abbasi,1Amir Gholamzad,2Mehrdad Gholamzad,3,*Mohammadmatin Nourikhani,4
1. Department of Microbiology, Faculty of Advanced Science And Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 2. Department of Laboratory Medicine, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 3. Department of Microbiology and Immunology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran 4. Department of Laboratory Medicine, Faculty of Paramedical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
Introduction: MSCs have been shown to regulate their local environment, activate endogenous progenitors through cell–cell interactions and the secretion of various factors, and play a role in tissue damage repair. MSCs can also produce a variety of growth factors and cytokines, such as transforming growth factor beta 1 (TGF-β1), vascular endothelial growth factor (VEGF), Interleukin-6 (IL-6), and chemokines (such as MCP-1), which play an important role in tissue repair and remodeling . These characteristics make MSCs an ideal therapeutic agent for treating RA.
Methods: This article reviews the clinical progress in MSC application for the treatment of rheumatic diseases.
Results: In recent years, the application of MSCs in rheumatic diseases has received increasing attention. On the one hand, MSCs have the ability to differentiate into bone and cartilage cells; on the other hand, these stem cells are also involved in immune regulation, resulting in the alleviation of inflammation and anti-fibrotic properties and the promotion of vascular repair, thus bringing new hope for the treatment of rheumatic diseases.
Conclusion: As a cell therapy, MSCT may cause capillary bed blockage, ectopic osteogenesis, chondrogenesis, tumor and other risks, which limits its clinical application to a certain extent. It is believed that with the gradual improvement of our understanding of the biological properties and clinical applications of MSCs, MSCT will have a wider application. Further research on MSCT will provide new perspectives and ideas for its use in the treatment of autoimmune diseases.