Application of stem cells in cardiovascular disorders
Application of stem cells in cardiovascular disorders
Niloofar Dehghan,1Tuba Zendehboudi,2Fatemeh Mohajer,3Fatemeh Madaddi,4Zohreh Farrar,5Neda Baghban,6,*
1. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 2. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 3. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 4. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 5. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 6. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Introduction: Introduction: One-third of all daily deaths are caused by cardiovascular disorders, making them one of the leading causes of death worldwide. One of the most recent and secure approaches to treating patients suffering from cardiovascular disorders such as ischemic heart and peripheral blood vessel disease is the use of stem cells.
Methods: Method: The current study is a descriptive-review analysis on the usefulness of stem cells derived from diverse sources in healing cardiovascular disorders. The selected papers have been published and are indexed in scientific databases such as PubMed, ISI, and Scopus. In this studied tried to properly explain the ability and mechanism of stem cells to increase or improve the healing process in cardiovascular disorders such as ischiatic condition.
Results: Result and discussions: Multipotent stem cells as well as precursors isolated from several tissues, including bone marrow, have been demonstrated to be able to restore the physiological activity of ischemic organs by enhancing their angiogenic potential. It has been demonstrated that stem cells can increase the blood flow to the ischemic area of the heart and speed up the repair process of the damaged areas through secretory (paracrine) mechanisms and differentiation into the endothelial cell line. Additionally, mesenchymal stem cells (MSCs) have been successfully used to treat patients who have had heart attacks and strokes. Recently, it has been reported that the injection of MSCs can restore heart function by secreting paracrine substances, despite the fact that they are essentially distinct from cardiac cells like cardiac muscle cells. Additionally, it has been discovered that MSCs release all paracrine substances in membrane vesicles known as exosomes, which exist in blood, urine, saliva, semen, serum, etc. They are also involved in various pathological processes such as cardiovascular, etc.
Conclusion: Conclusion: Stem cells induce proliferation in the surviving heart tissue and result in rebuilding and improving the damaged heart's tissue. Therefore, this novel treatment approaches can be recommended as an alternative of invasive surgical procedure for patients suffering from cardiovascular and heart failure.