• Application of stem cells in the treatment of nervous system diseases
  • Fatemeh Madadi,1 Zohreh Farrar,2 Niloofar Dehghan,3 Tuba Zendehboudi,4 Fatemeh Mohajer,5 Neda Baghban,6,*
    1. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    2. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    3. Student Research and Technology Committee, Bushehr University of Medical Sciences, Bushehr, Iran
    4. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    5. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
    6. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran


  • Introduction: Introduction: Stem cells are a population of undifferentiated cells that have the ability of proliferation, self-renewal and differentiation into specialized cell types. There are many reports about the potential of these cells in treating nervous system disorders.
  • Methods: Methods: The current study, which was carried out by exploring reputable medical databases, is a descriptive review of the potential benefits of stem cells in the treatment of nervous system illnesses.
  • Results: Results: Parkinson's, MS, Alzheimer's, stroke, brain and spinal cord injuries, amyotrophic lateral sclerosis, SMA, and cerebral palsy are a few of the neurological conditions that have been treated by cell therapy. For instance, stem cell transplantation may result in the production of chemicals that promote the survival or recovery of damaged nerve cells and lower inflammation in MS disease. Mesenchymal cells can be injected intravenously to travel within brain lesions and increase the survival rate of brain cells. Additionally, the injection of mesenchymal cells lessens the disease's severity and enhances the quality of life for MS patients. The researchers discovered that adult adipose tissue stem cells are among the best cells for treating MS because they improve sexual dysfunction and social interactions. Recent studies have shown that hematopoietic stem cell transplantation can stop the progression of MS disease in 70% to 80% of individuals for 4 to 5 years. Dopaminergic progenitor cells, which are produced from fetal cells and can serve as a renewable resource with high capacity, are also found in Parkinson's disease. And this approach is being studied. In the past 20 years, there has also been a surge in interest in using cell replacement therapy to treat neurodegenerative illnesses like Huntington's. The idea of treating spinal cord injuries with stem cells produced from human umbilical tissue and cells derived from bone marrow has been supported by a number of peer-reviewed articles and case reports. The potential for combined allogeneic stem cell therapy for spinal cord injury: By giving spinal cord injury patients treated at our centers stem cells Mesenchymal generated from umbilical cord tissue, we have witnessed benefits. Stem cells can help with all of these issues in cases of really complicated spinal injury. They are able to regenerate an environment, repair dead tissue, and produce new nerve cells.
  • Conclusion: Conclusion: Neurological problems can be treated with cell therapy, which is an intriguing and successful technique. Up till now, mesenchymal stem cells, neural stem cells, embryonic stem cells, and other cells have all been utilized to treat neurological diseases under in vitro condition and may soon represent a novel therapeutic approach for the management of neurological disorders.
  • Keywords: Keywords: Stem Cell, Nervous system disorders, Parkinson, Alzheimer