Stem cell-based tissue engineering approaches for burn wound healing
Stem cell-based tissue engineering approaches for burn wound healing
Niloofar Dehghan,1Tuba Zendehboudi,2Fatemeh Mohajer,3Fatemeh Madadi,4Zohreh Farrar,5Neda Baghban,6,*
1. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 2. Student Research and Technology Committee, Bushehr University of Medical Sciences, Bushehr, Iran 3. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 4. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 5. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran 6. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran
Introduction: Introduction: One of the skin wound models is the burn wound model. Many people die annually due to burns and tissue damage. One of the causes of this high mortality is the lack of biological and natural compounds compatible with the human body for treatment. Nowadays, stem cell-based tissue engineering therapeutic approaches have been proposed to treat these wounds.
Methods: Method: This study overviews advances of tissue engineering approaches for healing burn wound these approaches and give insights into mechanisms that aid burn wound healing in different clinical scenarios.
Results: Results: Addition to the conventional wound care practices, stem cells and tissue engineering approaches have been recently gained increased importance in healing burn wounds. Skin tissue engineering is a new solution for treating wounds and skin diseases, and its ultimate goal is to replace damaged tissues, to return to the functional state before complications, to overcome the limitations of conventional skin graft methods. Engineered tissues not only close wounds, but also stimulate the regeneration of the dermis, which is very useful for burn wound healing. Tissue engineering is based on the three main pillars of cells, scaffolds and growth factors. Stem cells are also used to treat a wide range of skin injuries and degenerative diseases. Currently, through the approach of skin tissue engineering and the application of biomaterials, it is used as a platform to improve the grafting of implanted stem cells and facilitate the function of cells by mimicking the tissue microenvironment to regenerate damaged skin tissue.
Conclusion: Conclusion: Stem cell- based tissue engineering strategies for burn wound healing have been developed over the past few decades and successful results have been obtained. However, all through the continual development of tissue engineering in bourn wound repair, a close collaboration between tissue engineers and clinicians is critical to maintain the translational efficacy of this approach.