مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
Investigating the risk factors and clinical characteristics and pathology of colorectal cancer in the population of Fars province
Investigating the risk factors and clinical characteristics and pathology of colorectal cancer in the population of Fars province
Sara Senemar,1,*Mohammad Javad Fatahi,,2Ali Zarei,3Hossein Javid,4Sara Sanjarian,5Saba Jahani,6
1. Human Genetic Research Group, Iranian Academic Center for Education, Culture & Research (ACECR), Fars Province Branch, Shiraz, Iran 2. Department of Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz Iran 3. Human Genetic Research Group, Iranian Academic Center for Education, Culture & Research (ACECR), Fars Province Branch, Shiraz, Iran 4. Human Genetic Research Group, Iranian Academic Center for Education, Culture & Research (ACECR), Fars Province Branch, Shiraz, Iran
Introduction: One of the most important types of cancer in the world is colorectal cancer (CRC), which has become a major health problem and is considered the cause of death in the world. Colorectal cancer is the third most common cancer in men and the second most common cancer in women in our country. Colorectal cancer is divided into two categories: hereditary and sporadic. Hereditary colorectal cancers account for 5 to 10% of colorectal cancers, while the rest are isolated colorectal cancers that occur due to somatic mutations in colon and rectal cells. Single-cell CRC occurs in old age and its maximum incidence is after the age of 50. Colorectal cancer is one of the most common malignant tumors, the prevalence of which is increasing in our country.
Among the risk factors of this disease, gender and age can be mentioned as important risk factors for colon cancer, so that, for example, women have more survival and less risk of dying from colon and rectal cancer than men. Regarding age, although the probability of colorectal cancer in middle-aged people is 5%, but 90% of people who have this cancer are more than 50 years old. A study in 1992 in Fars province showed that, with the exception of rectal cancer, the standard annual incidence rates cut off from the age of 25 (TAASIR) for other cancers examined in men were almost twice that of women, and this difference was statistically significant in the case of colon = 0.056. (P
The purpose of this study is to investigate the prevalence of risk factors and prognostic factors of colon cancer in these patients for proper planning to determine risk factors to control and prevent this cancer, because the severity and importance of risk factors and predisposing behaviors are different in each region and it is necessary to investigate these factors in each region. Risk and prognosis factors in this study include age, gender of patients, tumor size at the time of diagnosis, tumor grade, tumor stage, degree of invasion and tumor location.
Methods: The present study is a descriptive-cross-sectional study in which the information of 150 men and women with colon cancer confirmed by questioning and file review in Shiraz Medical Sciences Hospitals were selected in 1400 and were evaluated, examined and questioned in terms of non-modifiable factors (age and gender), clinical pathology, tumor characteristics, and the stages and proven prognosis of colon cancer by doctors and experienced people. The resulting data will be analyzed using SPSS version 16 software and frequency indices and chi-square test.
Results: In the present study, this disease was seen in men and women relatively equally. The highest risk factors in CRC are age over 50 years, percentage of involvement of Rectum and Cecum, type of adenoma tumor, tumor size 2-5 cm, histopathology of well-differentiated tissue and most patients in cancer stages (TNM) T in stage 3, N in stage 0 and M in stage 2.
Conclusion: Determining the impact of colon cancer risk factors and prognosis in any population for prevention can play an important role in reducing the incidence of this disease. If it is recommended to carry out more extensive studies considering the risk factors affecting colon cancer and the importance of doing digestive tests such as colonoscopy, blood tests in stool and test of colon cancer markers such as CA 125, CEA CA19-9.