Introduction: Laminin is one of the main proteins of the basement membrane and According to research is a target for thyroid cancer treatment .
Sorafenib is used in the therapy of advanced renal cell, liver and thyroid cancer .
Doxorubicin is an antibiotic in the treatment of many cancers, including blood , breast, stomach , uterine , ovarian , lung and thyroid cancer.
Vandetanib is a drug that is used to treat medullary thyroid cancer that cannot be treated with surgery or has spread to other parts of the body.
Sunitinib is a medicine which is used in the treatment of gastrointestinal tract, kidney, pancreas and advanced thyroid cancer .
Methods: First, prepared the three-dimensional structure of the laminin protein by using the Uniprot site .
Then, we obtain the three-dimensional structure of Sorafenib- Doxorubicin - sunitinib and Vandetanib drugs through the Pubchem site.
In the next step, using the Chimera 1.10.2 program, we include changes such as removing ions, adding hydrogen, removing extra chains, etc. in the original protein .
Finally, with the PyRx program, we start docking by loading the modified protein file as macromolecule and the drug file as input .
Conclusion: According to the investigations, sorfanib has the most effect on laminin protein, and Doxorubicin , Vandetanib and sunitinib have the most effect, respectively .
Keywords: unti-thyroid cancer drugs
laminin protein
molecular docking
thyroid cancer