• The effect of curcumin nanomicelle on embryo quality in women with Endometersis: a randomized controlled trial
  • Rahil Jannatifar ,1,* Seyedeh Saeideh Sahraei,2 Elham Asa,3 Atefeh Verdi,4 Mohadeseh Khoshandam,5 Leyla Naserpour,6
    1. Department of Reproductive Biology, Academic Center for Education Culture and Research (ACECR), Qom, Iran.
    2. Department of Reproductive Biology, Academic Center for Education Culture and Research (ACECR), Qom, Iran.
    3. Department of Reproductive Biology, Academic Center for Education Culture and Research (ACECR), Qom, Iran.
    4. Department of Reproductive Biology, Academic Center for Education Culture and Research (ACECR), Qom, Iran.
    5. Department of Reproductive Biology, Academic Center for Education Culture and Research (ACECR), Qom, Iran.
    6. 1. Department of Reproductive Biology, Academic Center for Education Culture and Research (ACECR), Qom, Iran. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Qom University of Medical Sciences, Qom, Iran


  • Introduction: Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. In this study, The effect of curcumin nanomicelle on embryo quality in women with Endometersis.
  • Methods: This clinical trial was conducted on 10 women with Endometersis, diagnosed according to the Rotterdam criteria, who were sequentially recruited and randomly divided into two groups (n = 5 each). group 1 received 80 mg/day curcumin nanomicelle three times daily, and group 2 (control group) not received curcumin nanomicelle. Data were analyzed by one-way ANOVA, with significance set at P < 0.05.
  • Results: The number of immature and abnormal oocytes decreased significantly in the treatment compared with control group (p<0.05), but a concomitant increase in the fertilization rate, cleavage rate, and number of good-quality embryos in the treatment group (P < 0.05). Malondialdehyde levels decreased significantly in the curcumin nanomicelle group compared with the control group (P < 0.05). In addition, there were significant decreases in leptin levels in the treatment group compared with the control group (P < 0.05). Insulin and LH levels were significantly lower in the curcumin nanomicelle group compared with the control group (P < 0.05).
  • Conclusion: We concluded that curcumin nanomicelle improves oocyte and embryo quality in women with Endometersis.
  • Keywords: Curcumin nanomicelle, Endometersis, Embryo quality