• Investigating changes in the expression of genes involved in the occurrence of hepatocellular carcinoma: a study Meta-analysis
  • Soheil Sabouri,1 Nazli Khajehnasiri,2 Fatemeh Zeinali,3 Salar Sabouri,4,*
    1. Research Institute of Bioscience and Biotechnology, university of Tabriz, Tabriz, Iran
    2. Department of Biological Sciences, Faculty of Basic Sciences, Higher Education Institute of Rab-Rashid, Tabriz, Iran
    3. Department of Biological Sciences, Faculty of Basic Sciences, Higher Education Institute of Rab-Rashid, Tabriz, Iran
    4. Research Institute of Bioscience and Biotechnology, university of Tabriz, Tabriz, Iran


  • Introduction: The latest studies show that hepatocellular carcinoma covers about 85% of people with liver cirrhosis; the poor development of hepatocellular carcinoma patients is because the effect of hepatocellular carcinoma in Early stages of the disease is not detectable, early and accurate detection of HCC can significantly improve the clinical treatment effect, with the discovery of HBV vaccine and HCV antiviral therapy, it is promising to reduce the incidence of hepatitis-related HCCs.
  • Methods: In this study, a set of gene expression data according to the microarray was obtained from the Gene (GEO Expression Omnibus NCBI) database, which is obtained from the accession numbers of the gene for the received data group, including GSE84005 with GPL5175, which is 76 samples. 38 samples Hepatocellular carcinoma cancer tumor and 38 normal hepatocellular carcinoma samples, the data obtained from the downloaded raw Affymetrix CEL file, robust multi-array median RMA for Log2 transformation, normalization and background correction pre-processed for The analysis was carried out through quality meri array in R.
  • Results: Based on the data that we found from the gene database and according to the analysis that we did in hepatocellular carcinoma, the genes and the path of the genes that increase the expression in different signaling pathways were examined. We have given that it is the same as the previous studies
  • Conclusion: Based on the analysis and investigations we have done, We concluded that in the tumor tissue relative to the margin, Tumors with -2< LogFC<2 increased expression and correlated with a P-value < 0.05, It has a meaning.
  • Keywords: Hepatocellular carcinoma (HCC), long non-coding RNA (lncRNA), mRNA, meta-analysis