مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
The relationship between serum zinc concentration and metabolic syndrome in HTLV-1 infected subjects
The relationship between serum zinc concentration and metabolic syndrome in HTLV-1 infected subjects
Samaneh Abolbashari,1Susan Darroudi,2Zahra Meshkat,3,*Majid Ghayour Mobarhan,4
1. Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2. International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 4. Mashhad University of Medical Sciences -
Introduction: Chronic Systemic inflammation is a probable factor that promotes the interplay between human T-lymphotropic virus type 1 (HTLV-1) infection and metabolic syndrome (Mets), and thus contributes to the progression of both. According to available evidence, Zinc (Zn) is one of the essential trace elements which can reduce inflammation and oxidative stress. In this study, we aimed to investigate the concentration of serum zinc and its association with metabolic syndrome among HTLV-1-infected individuals.
Methods: In this study 271 HTLV-1 infected subjects were divided into two groups, 154 with Mets and 117 without Mets according to IDF criteria. Serum zinc concentration was measured by flame atomic absorption. SPSS version 18 was used for data analyzing.
Results: The serum levels of zinc were significantly lower in individuals with Mets (p < 0.05). The body fat percentage (FAT) and serum high-sensitivity C-reactive protein (hs-CRP) were significantly higher in individuals with Mets (P <0.001 and P =0.025, respectively); whereas, no significant changes were seen in superoxide dismutase (SOD). According to multiple logistic regression analysis, after adjusting for age, sex, hs-CRP, and FAT, the risk of MetS in the quartiles 1,2 and 3 was 2.477 (1.298-4.726) compared to the 4th quartile.
Conclusion: Conclusion:
Our finding pointed to a significant association between serum concentration of zinc and the prevalence of metabolic syndrome (Mets) among individuals with HTLV-1 infection. Thus, regular screening for zinc intake and its serum levels may help HTLV-1 infected individuals reduce the risk of metabolic syndrome and prevent its subsequent complications.