Samira Malekzadeh,1,*Mohammad Amin Mosleh Shirazi,2Mohammad Amin Edalatmanesh,3Manzarbanoo Shojaeifard,4Zahra Khodabandeh,5Mehdi Dianatpour,6
1. Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran 2. Ionizing and non-ionizing radiation protection research center, Shiraz University of Medical Sciences, Shiraz, Iran 3. Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran 4. Ionizing and non-ionizing radiation protection research center, Shiraz University of Medical Sciences, Shiraz, Iran 5. Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran 6. Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Introduction: Stem cell therapy used in many branch of medicine and drug industry and regenerative medicine. X-ray and high level of radiation induces apoptosis, Reactive Oxygen Species ( ROS) production, and genotoxic stress like Double-strand breaks (DSBs) in Deoxyribonucleic (DNA).
Methods: Although, Low Ionizing Radiation (IR; about less than 1 Gray) increased the differentiation of stem cells repair DSBs in DNA. In addition, low level radiation to Adipose Mesenchymal Stem Cells (ADSCs) increased Stat3 expression and decreased g-H2AX and Rad51 at 24 hours after radiation.
Results: Low Traumatic brain injury ( TBI) resulting from damage brain cells temporarily, blow to the head or body in accident or shut gun wound. Also, the symptoms including, headache, nausea, fatigue, blurred vision, dizziness, and speech problems. Due to tissue sensitivity against radiation even low dose, especially the blood system and hematopoietic stem cells, it has become a European research priority network.
Conclusion: Furthermore, low dose radiation especially in gut and brain increased ROS, Superoxide dismutase 2 (SOD2), and activation of Nuclear factor kappa-light chain- enhancer of activated B cells (NFk ). On the other hand, injection of stem cells into the cerebrospinal fluid (CSF) significantly decrease the number of hippocampus dark neurons, enhanced synaptic plasticity, improved the spatial memory, and decreased apoptosis in the CA1 region hippocampus. Stem cell have multipotent capacity to differentiation cells and migrated into host cells. The long term therapy of stem cell could effective in mild brain injury.