مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
mRNA Vaccine Technology: a Novel Weapon in Treatment Infectious Diseases and Cancers
mRNA Vaccine Technology: a Novel Weapon in Treatment Infectious Diseases and Cancers
Shiva Mohammadi,1,*Mahdi Barazesh,2Leila Abkhooie,3Soudabe Kavousipour,4
1. Department of Medical Biotechnology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. 2. School of Paramedical Sciences, Gerash University of Medical Sciences, Gerash, Iran 4. Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Introduction: Infectious diseases and cancer have threatened human life, but with the progress of vaccines, practical approaches for preventing these diseases have become available. During recent decades, there has been comprehensive attention to RNA-based knowledge for developing therapeutic and prophylactic vaccines. mRNA vaccine technology can combat cancer and viral diseases due to efficacy, safety, and large-scale production advantages.
Methods: This study included peer-reviewed papers from Scopus, PubMed, Web of Science, and ScienceDirect databases from 2020 to 2023.
Results: mRNA vaccines can induce immune responses comprising both humoral and cellular immunity. Furthermore, mRNA is a fundamentally harmless vector as it is a negligible and only transient carrier of information that does not integrate into the genome. Since any protein can be expressed from mRNA without the essential to regulate the production process, mRNA construct vaccines also make extreme flexibility to development. Present investigation development on mRNA vaccines has the probable to be hasty-manufactured and to develop practical tools against infections (like SARS-CoV-2) and cancers.
Conclusion: Preclinical and clinical trials have revealed that mRNA technology offers a safe and long-lasting immune response in animal models and humans.