• Bioinformatics Evaluation of signaling pathways targeting SNP related to the FTO in Obesity
  • Farzaneh Ramezani Hombari,1,* Faranak Jamshidian,2 Maryam Rouhani,3
    1. Department of Biology , East Tehran Branch, Islamic Azad University , Tehran ,Iran
    2. Department of Biology , East Tehran Branch, Islamic Azad University , Tehran ,Iran
    3. Department of Tissue Engineering and Applied Cell Sciences , School of Advanced Technologies in Medicine , Shahid Beheshti University of Medical Sciences,Tehran,Iran


  • Introduction: Obesity has become a serious global problem that still needs a solution. One of the factors that leads to Obesity is genetic predisposition. The identity and characteristics of the genes involved have not yet been Fully confirmed. Analyzing the genetic contribution to obesity is a major step towards the solution. Recent Studies have shown that obesity is largely influenced by heredity and created by the interactions between Several genes and environmental and behavioral factors.
  • Methods: The gene is located on chromosome 16 and its The product plays an important role in energy metabolism.By investigating the role of single nucleotide polymorphism sequences in the FTO gene in the occurrence of obesity and It is effect on the occurrence of mutated genotypes in people. A modified version of this gene is considered the Strongest genetic risk factor for obesity NCBI, KEGG and DAVID database sites were used to find Bioinformatics.
  • Results: Rs9939609 is predicted to This protein participates in the Absorption, according to the bioinformatics study in the present project and also according to the Previous contents in the FTO study. Accordingly, the aim of the present study was to investigate the Influence of the polymorphism on post-training changes of selected body mass and body composition Measurements, as well as with Biochemical parameters of energy metabolism.
  • Conclusion: The role of different pathways in genes and SNP obesity can be determined in each person’s functional metabolism.
  • Keywords: FTO,SNP,Obesity,Gene