مقالات پذیرفته شده در هفتمین کنگره بین المللی زیست پزشکی
Investigating the Effect of Cytokine TNF-α on Tumor Cell Proliferation and Metastasis: A Preclinical Study and Systematic Review
Investigating the Effect of Cytokine TNF-α on Tumor Cell Proliferation and Metastasis: A Preclinical Study and Systematic Review
Seyed Sobhan Bahreiny,1,*Mojtaba Aghaei,2Mohammad Mehdi abolhasani,3Mohammad Reza Dabbagh,4Ehsan Sarbazjoda,5Mohammad Sharif Sharifani,6
1. Medical Basic Sciences Research Institute, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 2. Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 3. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 4. Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran. 5. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 6. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Introduction: Introduction: Thyroid hormones exert multiple effects on the testis and influence various cell types, including Leydig, Sertoli, and germ cells. Thyroid hormone deficiency can lead to testicular dysfunction, which manifests as abnormalities of seminal fluid. This systematic review in conjunction with a meta-analysis attempts to compare hypothyroidism with semen quality parameters that include sperm count, motility, and morphology.
Methods: MATERIALS AND METHODS: A comprehensive literature search was conducted to identify appropriate studies in PubMed, Scopus, Embase, and Web of Science databases, without geographic or language restrictions. Seven studies that met the eligibility criteria were selected, and the collected data were analysed using Comprehensive Meta-Analysis V3 software for meta-analysis.
Results: Findings: Ultimately, 7 studies with a total of 3497 participants were included. Cases of subclinical hypothyroidism had statistically significant reductions in total sperm count (SMD: -0.75, 95% CI: -1.29 to -0.21), normal sperm morphology (SMD: -0.99, 95% CI: -2.12 to -0.12), and progressive sperm motility (SMD: -1.56, 95% CI: -2.78 to -0.34) compared to control groups.
Conclusion: CONCLUSION: Consequently, scientific evidence supports the claim that semen quality parameters change in patients with hypothyroidism compared to their healthy counterparts. Thus, independent of other factors, hypothyroidism may play a crucial role in altering spermatogenesis and contribute to male infertility.