Introduction: Breast cancer is the most common cancer type in females in the Western world. It is caused by a combination of genetic and environmental factors. The risk of developing breast cancer increases with age, family history, and certain lifestyle factors, such as obesity and smoking.
Methods: Microarray technology is a powerful tool that can be used to study gene expression profiles in breast cancer. This can help researchers to identify genes that are differentially expressed in breast cancer and gain insights into the pathways and biological processes that are dysregulated in the disease.
Results: EGCG and apigenin are two naturally occurring compounds that have been shown to have anti-cancer properties. Previous studies have shown that EGCG and apigenin can induce changes in gene expression in cancer cells. However, the results of these studies have been inconsistent.
Conclusion: A meta-analysis of these studies was conducted to provide a more accurate assessment of the effects of EGCG and apigenin on gene expression in breast cancer cells. The results showed that both EGCG and apigenin can induce changes in gene expression in breast cancer cells, including genes involved in cell proliferation, apoptosis, and angiogenesis.
Keywords: Breast cancer, Gene expression, Meta-analyses, Apigenin, EGCG